Document Detail

Interrelations between coronary artery pressure, myocardial metabolism and coronary blood flow.
MedLine Citation:
PMID:  2388275     Owner:  NLM     Status:  MEDLINE    
Characteristically, the coronary circulation has been studied in the time-honored way of varying a single experimental variable while attempting to hold other hemodynamic variables constant. This has produced two-dimensional descriptions of coronary physiology where coronary blood flow vs. coronary artery perfusion pressure, or coronary blood flow vs. myocardial oxygen consumption, are plotted. However, the physiology is more complicated than these plots can show, because coronary blood flow and myocardial metabolism interact. Accordingly, a three-dimensional analysis of coronary physiology has been made where coronary artery pressure and myocardial oxygen consumption are the primary determinants of coronary blood flow, but interactions among all three variables are included. Data on coronary autoregulation and myocardial oxygen consumption have been combined, while maintaining mass balance, to form a three-dimensional surface that describes local metabolic control of coronary blood flow. Using this description of state in three dimensions, simulations of coronary physiology with and without coronary artery stenosis were performed which provide insight into the simultaneous variations in coronary artery pressure, myocardial metabolism and coronary blood flow.
E O Feigl; G W Neat; A H Huang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of molecular and cellular cardiology     Volume:  22     ISSN:  0022-2828     ISO Abbreviation:  J. Mol. Cell. Cardiol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-09-25     Completed Date:  1990-09-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0262322     Medline TA:  J Mol Cell Cardiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-90     Citation Subset:  IM    
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.
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MeSH Terms
Aortic Valve Stenosis / physiopathology
Automatic Data Processing
Blood Pressure
Coronary Circulation / physiology*
Coronary Disease / physiopathology
Myocardium / metabolism*
Oxygen Consumption
Oxyhemoglobins / metabolism
Ventricular Function
Grant Support
Reg. No./Substance:

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