Document Detail

Interrelation between whole-body turnover rates of RNA and protein.
MedLine Citation:
PMID:  1702054     Owner:  NLM     Status:  MEDLINE    
In our search for new non-invasive methods to determine metabolic and nutritional state, we have identified several specific, modified, urinary one-way catabolites of rRNA, tRNA and mRNA which permit the assessment of the whole-body turnover of these RNA classes. A comparison of the steady-state turnover of RNA and the proteins actin plus myosin (determined using urinary 3-methylhistidine) in preterm infants and adults showed that preterm infants have about 3 times higher average turnover rates per unit body weight than adults of tRNA and rRNA as well as of actin plus myosin, whereas calculated mRNA turnover was 6 times higher in preterm infants than in adults. These as well as our recent observations of RNA turnover in different mammals are compared here with data on whole-body protein turnover and basal metabolic rates (BMR) in different mammalian species including man, for which data are available. The turnover rates of tRNA, rRNA, protein and energy (BMR) can be described by the relation, turnover = const. x body mass (exp.), the extrapolated exponents being 0.69-0.78. This suggests a common underlying principle, possibly energy turnover, as cause for the coordinated whole-body turnover rates of RNA and protein in the steady state.
G Schöch; H Topp; A Held; G Heller-Schöch; A Ballauff; F Manz; G Sander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  44     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-02-01     Completed Date:  1991-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  647-58     Citation Subset:  IM    
Forschungsinstitut für Kinderernährung, Dortmund 50, Federal Republic of Germany.
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MeSH Terms
Basal Metabolism*
Body Weight
Chromatography, High Pressure Liquid
Creatinine / urine
Guanine / analogs & derivatives,  urine
Infant, Newborn
Methylhistidines / urine
Muscle Proteins / metabolism
Nutritional Status
Proteins / metabolism*
RNA / metabolism*
Reg. No./Substance:
0/Methylhistidines; 0/Muscle Proteins; 0/Proteins; 368-16-1/3-methylhistidine; 578-76-7/7-methylguanine; 60-27-5/Creatinine; 63231-63-0/RNA; 73-40-5/Guanine

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