Document Detail


Interrelation between factor VII, prekallikrein, and hyperfibrinolysis in advanced cirrhosis.
MedLine Citation:
PMID:  2613916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Factor VII and prekallikrein activities were studied in 37 patients with liver cirrhosis who were in a decompensated state. Sixteen of them died 30-70 days after admission; 21 survived and were discharged after 30-80 days. Seven who died and six survivors had signs of hyperfibrinolysis: factor VII activity differentiated the two groups independently of the presence of hyperfibrinolysis. The presence of hyperfibrinolysis significantly reduced prekallikrein activity, which did not differentiate clearly survivors from non-survivors. Long term follow up of survivors showed a good correlation between factor VII and prekallikrein activities with long term survival. Hyperfibrinolysis seemed to influence the clinical course of patients: 87% of patients with hyperfibrinolysis who died had fatal haemorrhagic episodes. Low factor VII activity may be a precursor of terminal liver insufficiency.
Authors:
F Violi; C Alessandri; D Ferro; M Saliola; C Cordova; A Musca; F Balsano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  42     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-03-09     Completed Date:  1990-03-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1246-9     Citation Subset:  AIM; IM    
Affiliation:
Istituto di I Clinica Medica, University La Sapienza, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Bilirubin / blood
Blood Coagulation Disorders / complications
Factor VII / metabolism*
Female
Fibrinolysis / physiology*
Humans
Liver Cirrhosis / blood*,  complications,  mortality
Male
Middle Aged
Prekallikrein / metabolism*
Prognosis
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; 9001-25-6/Factor VII; 9055-02-1/Prekallikrein
Comments/Corrections

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