| Interrelation between factor VII, prekallikrein, and hyperfibrinolysis in advanced cirrhosis. | |
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MedLine Citation:
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PMID: 2613916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Factor VII and prekallikrein activities were studied in 37 patients with liver cirrhosis who were in a decompensated state. Sixteen of them died 30-70 days after admission; 21 survived and were discharged after 30-80 days. Seven who died and six survivors had signs of hyperfibrinolysis: factor VII activity differentiated the two groups independently of the presence of hyperfibrinolysis. The presence of hyperfibrinolysis significantly reduced prekallikrein activity, which did not differentiate clearly survivors from non-survivors. Long term follow up of survivors showed a good correlation between factor VII and prekallikrein activities with long term survival. Hyperfibrinolysis seemed to influence the clinical course of patients: 87% of patients with hyperfibrinolysis who died had fatal haemorrhagic episodes. Low factor VII activity may be a precursor of terminal liver insufficiency. |
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Authors:
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F Violi; C Alessandri; D Ferro; M Saliola; C Cordova; A Musca; F Balsano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical pathology Volume: 42 ISSN: 0021-9746 ISO Abbreviation: J. Clin. Pathol. Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-03-09 Completed Date: 1990-03-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0376601 Medline TA: J Clin Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1246-9 Citation Subset: AIM; IM |
Affiliation:
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Istituto di I Clinica Medica, University La Sapienza, Rome, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Bilirubin / blood Blood Coagulation Disorders / complications Factor VII / metabolism* Female Fibrinolysis / physiology* Humans Liver Cirrhosis / blood*, complications, mortality Male Middle Aged Prekallikrein / metabolism* Prognosis |
| Chemical | |
Reg. No./Substance:
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635-65-4/Bilirubin; 9001-25-6/Factor VII; 9055-02-1/Prekallikrein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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