Document Detail

Interrelation between arterial inflammation in acute coronary syndrome and circadian variation.
MedLine Citation:
PMID:  21390198     Owner:  NLM     Status:  PubMed-not-MEDLINE    
At present, the study into inflammatory markers has become a new tool which is most useful for establishing the prognosis of patients with acute coronary syndrome. The inflammatory substrate involved is acute coronary syndrome is extremely complex, with a large number of factors involved both in its activation and its modulation. It is known that C-reactive protein play a key role in the physiopathology of the atherosclerosis. Furthermore, scientific literature reports that the existence of a circadian rhythm in the triggering of cardiovascular accidents can suggest the implication of, or association with these physiological rhythms that show activity peaks at particular times of the day or night. Keeping in mind the potential association between inflammation and circadian rhythm, a better understanding of the kinetics of said markers could lead to improvements in their use in cardiovascular diseases. Considering the diversity of the diurnal variations in the intrinsic properties of the cardiovascular system, these should be kept in mind during the design of in vivo experimental studies. As such, the information available reinforces our opinion when suitably validating the biomarkers and the need to demonstrate their reliability, stability, and lack of variability and standardise the methodology of their measurement.
Alberto Dominguez-Rodriguez; Maria Carrillo-Perez Tome; Pedro Abreu-Gonzalez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of cardiology     Volume:  3     ISSN:  1949-8462     ISO Abbreviation:  World J Cardiol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-10     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101537090     Medline TA:  World J Cardiol     Country:  China    
Other Details:
Languages:  eng     Pagination:  57-8     Citation Subset:  -    
Alberto Dominguez-Rodriguez, Maria Carrillo-Perez Tome, Department of Cardiology, Hospital Universitario de Canarias, Tenerife, E-38320, Spain.
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