| Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study. | |
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MedLine Citation:
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PMID: 21317270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Stroke is an important cause of death and disability among children. Clinical trials for childhood stroke require a valid and reliable acute clinical stroke scale. We evaluated interrater reliability (IRR) of a pediatric adaptation of the National Institutes of Health Stroke Scale. METHODS: The pediatric adaptation of the National Institutes of Health Stroke Scale was developed by pediatric and adult stroke experts by modifying each item of the adult National Institutes of Health Stroke Scale for children, retaining all examination items and scoring ranges of the National Institutes of Health Stroke Scale. Children 2 to 18 years of age with acute arterial ischemic stroke were enrolled in a prospective cohort study from 15 North American sites from January 2007 to October 2009. Examiners were child neurologists certified in the adult National Institutes of Health Stroke Scale. Each subject was examined daily for 7 days or until discharge. A subset of patients at 3 sites was scored simultaneously and independently by 2 study neurologists. RESULTS: IRR testing was performed in 25 of 113 a median of 3 days (interquartile range, 2 to 4 days) after symptom onset. Patient demographics, total initial pediatric adaptation of the National Institutes of Health Stroke Scale scores, risk factors, and infarct characteristics in the IRR subset were similar to the non-IRR subset. The 2 raters' total scores were identical in 60% and within 1 point in 84%. IRR was excellent as measured by concordance correlation coefficient of 0.97 (95% CI, 0.94 to 0.99); intraclass correlation coefficient of 0.99 (95% CI, 0.97 to 0.99); precision measured by Pearson ρ of 0.97; and accuracy measured by the bias correction factor of 1.0. CONCLUSIONS: There was excellent IRR of the pediatric adaptation of the National Institutes of Health Stroke Scale in a multicenter prospective cohort performed by trained child neurologists. |
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Authors:
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Rebecca N Ichord; Rachel Bastian; Lisa Abraham; Rand Askalan; Susan Benedict; Timothy J Bernard; Lauren Beslow; Gabrielle Deveber; Michael Dowling; Neil Friedman; Heather Fullerton; Lori Jordan; Li Kan; Adam Kirton; Catherine Amlie-Lefond; Daniel Licht; Warren Lo; Chalmer McClure; Steve Pavlakis; Sabrina E Smith; Marilyn Tan; Scott Kasner; Abbas F Jawad |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-11 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 42 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-21 Completed Date: 2011-04-19 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 613-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Children's Hospital of Philadelphia, Colket Translational Research Building 10th Floor, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA. ichord@email.chop.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Cohort Studies Female Humans Male National Institutes of Health (U.S.) / standards* Observer Variation Pilot Projects Prospective Studies Reproducibility of Results Severity of Illness Index* Stroke / diagnosis*, epidemiology* United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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K02-NS053883/NS/NINDS NIH HHS; K12 NS049453/NS/NINDS NIH HHS; K12-NS049453/NS/NINDS NIH HHS; K23-HL096895/HL/NHLBI NIH HHS; K23-NS062110/NS/NINDS NIH HHS; K23-NS52380/NS/NINDS NIH HHS; KL2-RR024983/RR/NCRR NIH HHS; R01 NS050488-01A1/NS/NINDS NIH HHS; R01-NS050488/NS/NINDS NIH HHS; R01-NS062820/NS/NINDS NIH HHS; T32 NS007413/NS/NINDS NIH HHS; T32-NS007413/NS/NINDS NIH HHS |
| Comments/Corrections | |
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