Document Detail

Interpreting periodic lung function tests in individuals: the relationship between 1- to 5-year and long-term FEV1 changes.
MedLine Citation:
PMID:  16899850     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV(1) declines. We sought to describe the relationship between FEV(1) changes over 1 to 5 years and FEV(1) declines over longer terms, using 21,821 test results from 1,884 workers who participated in an annual health monitoring program at a chemical plant between 1973 and 2003. METHODS: Test results from workers with five or more valid results over > or = 10 years were included in our analysis (mean initial worker age, 35 years; range, 18 to 62 years; 91% male; 35% current smokers and 41% nonsmokers). For each worker, long-term FEV(1) slopes (milliliters per year) were calculated by simple linear regression using all available results and compared to changes in FEV(1) between two tests over 1 to 5 years, expressed in both milliliters and percentage of initial value. RESULTS: Long-term (mean, 18 years; range, 10 to 30 years) slopes averaged - 29.1 mL/yr (- 27, - 29, and - 37 mL/yr for male never-smokers, former smokers, and current smokers, and - 20, - 26, and - 27 mL/yr for female never-smokers, former smokers, and current smokers, respectively). Excessive short-term and long-term declines were defined by lower fifth percentile values. Individuals with abnormal short-term declines were found to be 3 to 18 times more likely to ultimately show excessive long-term declines; with the strength of the association increasing with the length of the short-term testing interval. Better test operating characteristics resulted if abnormal short-term FEV(1) change was based on percentage change (ie, percentage per year) rather than absolute change (ie, milliliters per year). CONCLUSIONS: Our findings provide guidance for interpreting periodic spirometry results from individuals exposed to respiratory hazards.
Mei Lin Wang; Bipin H Avashia; Edward L Petsonk
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  130     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  AIM; IM    
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA.
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MeSH Terms
Disease Progression
Follow-Up Studies
Forced Expiratory Volume / physiology*
Lung Diseases / diagnosis*,  physiopathology
Middle Aged
Occupational Diseases / diagnosis*,  physiopathology
Occupational Exposure / adverse effects
Reproducibility of Results
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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