| Interpreting genetic effects through models of cardiac electromechanics. | |
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MedLine Citation:
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PMID: 23042948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Multiscale models of cardiac electromechanics are being increasingly focused on understanding how genetic variation and environment underpin multiple disease states. In this paper we review the current state of the art in both the development of specific models and the physiological insights they have produced. This growing research body includes the development of models for capturing the effects of changes in function in both single and multiple proteins in both specific expression systems and in vivo contexts. Finally, the potential for using this approach for ultimately predicting phenotypes from genetic sequence information is discussed. |
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Authors:
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S A Niederer; S Land; S W Omholt; N P Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2012-10-05 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 303 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-03 Completed Date: 2013-02-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1294-303 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, King's College London, King's Health Partners, Saint Thomas' Hospital, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Computer Simulation* Electrophysiological Phenomena / physiology* Genotype Heart / physiology* Heart Diseases / genetics*, physiopathology Humans Mice Models, Animal Models, Genetic Phenotype |
| Grant Support | |
ID/Acronym/Agency:
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1 P50 GM094503-01/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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