Document Detail

Interpreting genetic effects through models of cardiac electromechanics.
MedLine Citation:
PMID:  23042948     Owner:  NLM     Status:  MEDLINE    
Multiscale models of cardiac electromechanics are being increasingly focused on understanding how genetic variation and environment underpin multiple disease states. In this paper we review the current state of the art in both the development of specific models and the physiological insights they have produced. This growing research body includes the development of models for capturing the effects of changes in function in both single and multiple proteins in both specific expression systems and in vivo contexts. Finally, the potential for using this approach for ultimately predicting phenotypes from genetic sequence information is discussed.
S A Niederer; S Land; S W Omholt; N P Smith
Related Documents :
21737578 - The role of climate variability and change in the transmission dynamics and geographic ...
24062658 - Minimal self-models and the free energy principle.
25143968 - Analyzing big data with the hybrid interval regression methods.
24848698 - Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccha...
24738008 - Independent component analysis of instantaneous power-based fmri.
10370178 - Uncertainty quantification in the health consequences of the boiling liquid expanding v...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-10-05
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-02-12     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1294-303     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Computer Simulation*
Electrophysiological Phenomena / physiology*
Heart / physiology*
Heart Diseases / genetics*,  physiopathology
Models, Animal
Models, Genetic
Grant Support
1 P50 GM094503-01/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Exogenous ubiquitin modulates chronic ?-adrenergic receptor-stimulated myocardial remodeling: role i...
Next Document:  Inhibition of I kappaB Phosphorylation Prevents Load-induced Cardiac Dysfunction in Mice.