Document Detail

Interpreting the carboxyhaemoglobin concentration in fetal cord blood.
MedLine Citation:
PMID:  2778293     Owner:  NLM     Status:  MEDLINE    
We calculated the fetal-to-maternal carboxyhaemoglobin concentration ratio in 19 mother-infant pairs at the time of term delivery. Mothers, who had a less than 10% drop in their carboxyhaemoglobin concentration during labour, had an average ratio of 1.40 +/- 0.19. For mothers whose carboxyhaemoglobin concentrations dropped by 10% or more during labour, the average fetal-to-maternal carboxyhaemoglobin concentration ratio was 1.83 +/- 0.48. There was a strong correlation (r = 0.82) between the percent change in maternal carboxyhaemoglobin concentration during labour and the fetal-to-maternal carboxyhaemoglobin concentration ratio at the time of delivery. We conclude that increased CO elimination during labour may be accompanied by rapid changes in the maternal carboxyhaemoglobin concentration, leading to a spuriously high fetal-to-maternal carboxyhemoglobin concentration ratio at the time of delivery.
M B Leonard; H J Vreman; J E Ferguson; D W Smith; D K Stevenson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  11     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-10-20     Completed Date:  1989-10-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Pediatrics, Stanford University School of Medicine, California 94305.
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MeSH Terms
Carbon Monoxide / blood
Carboxyhemoglobin / analysis*
Fetal Blood / analysis*
Hyperventilation / complications
Infant, Newborn
Labor, Obstetric
Maternal-Fetal Exchange*
Smoking / blood
Grant Support
Reg. No./Substance:
630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

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