| Interpretation of reverse redistribution of 99mTc-tetrofosmin in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 12458393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reverse redistribution (RR) of technetium-99m tetrofosmin (TF) in patients with acute myocardial infarction (AMI) has been considered a sign of salvaged myocardium. We examined the time evolution of the RR pattern during a 6-month period and the clinical implications of RR. TF myocardial SPET was performed in 22 patients 1 week, 1 month and 3-6 months after AMI. Myocardial images were obtained 30 min and 180 min after the injection of TF. Regional uptake of TF was rated using a four-point scoring system. RR was defined as an increase of more than 1 point in the regional score on images obtained at 180 min. Echocardiography was performed to assess regional wall motion at the same time as TF imaging. RR observed at 1 week tended to disappear after 1 month and 3-6 months. The incidence of regional wall motion abnormality was reduced in patients with RR compared with that in patients with fixed defects. Recovery of abnormal regional wall motion occurred earlier in segments with disappearance of RR than in those without disappearance of RR. It is concluded that RR may reflect salvaged myocardium and that disappearance of RR may indicate earlier recovery of salvaged myocardium. |
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Authors:
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Yoshihide Hirata; Michitaka Takamiya; Noriyuki Kinoshita; Hiroyuki Yamada; Takatomo Shima; Hiroshi Miyazaki; Yoshio Kouno; Naohisa Sawada; Kenzou Sakamoto; Hiroki Sugihara |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2002-09-19 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 29 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-29 Completed Date: 2003-08-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 1594-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan. kissmeyh@gaia.eonet.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary Female Follow-Up Studies Heart Ventricles / metabolism*, radionuclide imaging, ultrasonography Humans Male Metabolic Clearance Rate Middle Aged Myocardial Infarction / metabolism*, radionuclide imaging*, therapy, ultrasonography Myocardial Reperfusion Organophosphorus Compounds / diagnostic use*, pharmacokinetics* Organotechnetium Compounds / diagnostic use*, pharmacokinetics* Predictive Value of Tests Radiopharmaceuticals / diagnostic use, pharmacokinetics Single-Blind Method Tissue Distribution Tissue Survival Tomography, Emission-Computed, Single-Photon / methods Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Radiopharmaceuticals; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane |
| Comments/Corrections | |
Comment In:
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Eur J Nucl Med Mol Imaging. 2003 May;30(5):798-9
[PMID:
12658508
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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