Document Detail

Interpretation of extravascular thermal volume of the lung in patients with chronic pulmonary diseases.
MedLine Citation:
PMID:  8552859     Owner:  NLM     Status:  MEDLINE    
To understand the significance of measured extravascular thermal volume of the lung (ETVL) in chronic pulmonary diseases, we measured ETVL using the double-indicator dilution technique in 17 emphysematous patients and 15 patients with pulmonary fibrosis. The level of ETVL in emphysema is significantly correlated with parameters reflecting the severity of the disease, including FEV1.0% (r = 0.54, p < 0.05), DLCO/VA (r = 0.54, p < 0.05), PaO2 (r = 0.61, p < 0.01), and mean pulmonary artery pressure (r = -0.61, p < 0.01). In pulmonary fibrosis, a significant inverse correlation was found between ETVL and PaO2 (r = -0.64, p < 0.02), DLCO/VA (r = -0.58, p < 0.05), and %VC (r = -0.61, p < 0.02). The mean level of ETVL in both groups of patients was lower than previously reported normal values. These results suggest that ETVL may reflect the decrease in pulmonary vasculature in emphysematous patients, while it may signify a decrease of pulmonary vasculature and increased volume of pulmonary interstitial tissue surrounding the pulmonary vasculature in pulmonary fibrosis. We conclude that ETVL may represent a good estimate of the condition of the pulmonary vasculature and interstitial tissue volume in patients with chronic pulmonary diseases.
S Ikeda; Y Miyahara; T Naitoh; S Kubo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  62     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  302-6     Citation Subset:  IM    
Second Department of Internal Medicine, Nagasaki University, School of Medicine, Japan.
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MeSH Terms
Capillaries / pathology
Catheterization, Swan-Ganz
Extravascular Lung Water / physiology*
Forced Expiratory Volume
Indicator Dilution Techniques
Indicators and Reagents
Lung / blood supply,  pathology
Middle Aged
Oxygen / blood
Pulmonary Alveoli / pathology
Pulmonary Diffusing Capacity
Pulmonary Emphysema / pathology,  physiopathology*
Pulmonary Fibrosis / pathology,  physiopathology*
Pulmonary Wedge Pressure
Sodium Chloride / diagnostic use
Vascular Resistance
Ventilation-Perfusion Ratio
Vital Capacity
Reg. No./Substance:
0/Indicators and Reagents; 7647-14-5/Sodium Chloride; 7782-44-7/Oxygen

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