Document Detail


Interpretation of the TDx-FLM fluorescence polarization assay in pregnancies complicated by diabetes mellitus.
MedLine Citation:
PMID:  9259935     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this paper is to determine the applicability of the Abbott TDx-FLM fluorescence polarization assay in pregnancies complicated by diabetes mellitus. Retrospective review of records of women with pregnancies complicated by diabetes who underwent amniocentesis for fetal lung maturity using the Abbott TDx-FLM assay within 3 days of delivery was considered. Maternal diabetic control, neonatal birth weight, Apgar scores, umbilical cord gases, admissions to Neonatal Intensive Care Unit (NICU), development of respiratory distress syndrome (RDS) were evaluated. One hundred twenty-one patients with diabetes mellitus were identified. Thirteen (10.7%) had an FLM < or = 70 mg/g and 108 patients had > or = 70 mg/g. All obstetrical and diabetic variables were similar. RDS was not observed in neonates who had an FLM of > or = 70 mg/g. One neonate had RDS (FLM = 7.2 mg/g). The TDx-FLM > or = 70 mg/g may be interpreted as mature when obtained from transabdominal amniocentesis.
Authors:
G O Del Valle; C D Adair; E E Ramos; F L Gaudier; L Sanchez-Ramos; R Morales
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-09-04     Completed Date:  1997-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Affiliation:
Regional Obstetric Consultants, Jacksonville, FL 32207, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Albumins / analysis*
Amniocentesis
Amniotic Fluid / chemistry*
Birth Weight
Female
Fetal Organ Maturity*
Fluorescence Polarization Immunoassay / methods*
Gestational Age
Humans
Infant, Newborn
Lung / embryology
Phosphatidylglycerols / analysis*
Pregnancy
Pregnancy Outcome
Pregnancy in Diabetics / complications*
Respiratory Distress Syndrome, Newborn / diagnosis*
Retrospective Studies
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Albumins; 0/Phosphatidylglycerols

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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