| Interpretability of PET/CT imaging in head and neck cancer patients following composite mandibular resection and osteocutaneous free flap reconstruction. | |
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MedLine Citation:
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PMID: 17694556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We investigated positron emission tomography (PET)/CT scanning following segmental resections and osteocutaneous free-flap reconstruction. The interpretability of PET/CT imaging with healing osteotomies and reconstruction hardware was analyzed. METHODS: Patient scans within 18 months of surgery were interpreted for malignancy. Interpretations were compared with clinical data to determine sensitivity/specificity. Standardized uptake values (SUVs) were determined for bony controls, osteotomies, and tumors and were analyzed using paired t test. RESULTS: Fifteen scans were visually interpreted, 13 underwent SUV analysis. Reconstruction hardware did not interfere with interpretability. Sensitivity and specificity were 88% and 86%, respectively. Osteotomy sites averaged 25% higher SUVs compared with bony controls (vs sternum p = .003, vs mandible p = .008). Tumor SUVs were higher than osteotomies (p = .023) and controls (vs sternum p = .013, vs mandible p = .025). CONCLUSION: Although osteotomies were characterized by an increased fluorodeoxyglucose signal, scan interpretability was unimpaired. Our study suggests that PET/CT imaging can be utilized to survey free-flap patients at acceptable levels of sensitivity/specificity. |
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Authors:
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Christopher Oliver; Ashok Muthukrishnan; James Mountz; Erin Deeb; Jonas Johnson; Frederic Deleyiannis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 30 ISSN: 1043-3074 ISO Abbreviation: Head Neck Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-15 Completed Date: 2008-05-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 187-93 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, University of Pittsburgh Eye and Ear Institute, 200 Lothrop St., Suite 500, Pittsburgh, Pennsylvania 15213-2546, USA. olivercl@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Head and Neck Neoplasms / diagnosis*, radiography, surgery* Humans Image Processing, Computer-Assisted Male Mandible / surgery* Middle Aged Osteotomy Positron-Emission Tomography / methods* Retrospective Studies Sensitivity and Specificity Surgical Flaps* Tomography, X-Ray Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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