Document Detail

Interpregnancy Interval and Anti-inflammatory Cervical Cytokines among Women with Previous Spontaneous Preterm Birth.
MedLine Citation:
PMID:  25486289     Owner:  NLM     Status:  Publisher    
Objective Both history of spontaneous preterm birth (sPTB) and shorter interpregnancy intervals (IPIs) increase the risk of recurrent sPTB. Mechanisms underlying the association between IPI and recurrent sPTB are unknown. We have previously demonstrated that higher concentrations of cervical anti-inflammatory cytokines are a risk factor for sPTB and upper genital tract inflammation. Here, we examine the association between IPI and cervical anti-inflammatory cytokines among women with previous sPTB. Patients and Methods  A prospective cohort of 73 women with previous sPTB and cervical interleukins (IL-4, IL-10, and IL-13) measured at < 16 weeks. Using the published principal factor analysis, the anti-inflammatory (ANTI) score was calculated. From our previous work, higher ANTI scores increase the subsequent risk of sPTB. IPI was the time from the previous birth to the conception of current pregnancy. Confounders included education level, marital status, gonorrhea, chlamydia, body mass index, race, and cigarette smoking. IPI and ANTI score were analyzed using univariable and multivariable analyses. Results There was a significant negative linear relation between IPI and ANTI score (β = -0.075, p = 0.017). This persisted after adjustment for confounders (p = 0.02). As IPI decreases by 1 month, the ANTI-score-associated risk of sPTB increases approximately by 4%. Conclusion Among women with previous sPTB, there was a significant negative linear relation between IPI and ANTI score.
Raj Shree; Hyagriv N Simhan
Related Documents :
25179669 - An updated meta-analysis of the signal transducer and activator of transcription 4 (sta...
16431309 - Risk factors for diseases of ileal pouch-anal anastomosis after restorative proctocolec...
20693149 - Low seroprevalence of syphilis in burkina faso.
24623069 - Measuring adherence by visual inspection of returned empty gel applicators in the capri...
25475899 - Is aspirin use associated with age-related macular degeneration? a meta-analysis.
19337849 - Seroprevalence estimation and management factors associated with high herd seropositivi...
8620339 - Higher serum bilirubin is associated with decreased risk for early familial coronary ar...
1609919 - Education, race, and high-density lipoprotein cholesterol among us adults.
15809459 - The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-8
Journal Detail:
Title:  American journal of perinatology     Volume:  -     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Risk Factors and Outcomes of Late-Onset Bacterial Sepsis in Preterm Neonates Born at?<?32 Weeks' Ges...
Next Document:  Randomized Comparison of Nifedipine and Placebo in Fibronectin-Negative Women with Symptoms of Prete...