| Interplay of portal pressure, portal perfusion and hepatic arterial inflow in modulating expression of hepatic encephalopathy in patients with spontaneous or artificially created portosystemic shunts. | |
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MedLine Citation:
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PMID: 15025249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The major theme of this discussion is how portal pressure after portosystemic shunt procedures may modulate the expression of hepatic encephalopathy. Decades of emphasis on the paramount importance of maintaining portal venous perfusion after shunt procedures is now being re-examined. In countries where non-cirrhotic portal hypertension is common, physicians have long recognized that hepatic encephalopathy is rare even with total portosystemic shunting. However, once decompressive shunts are created, hepatic encephalopathy becomes a clinical problem. Why this occurs needs to be better understood. In the meantime, there has been virtual abandonment of surgical shunts in favor of endoscopic variceal ablation treatment. This is despite the fact that surgical shunts that only partially decompress the portal hypertension are associated with excellent long-term control of variceal bleeding and low rates of hepatic encephalopathy. The time has come to once again examine the key relationship between portal pressure, portal perfusion with hepatic arterial inflow in inducing hepatic encephalopathy after creation of portosystemic shunts. |
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Authors:
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Kevin D Mullen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology Volume: 22 Suppl 2 ISSN: 0254-8860 ISO Abbreviation: Indian J Gastroenterol Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-03-17 Completed Date: 2004-04-23 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8409436 Medline TA: Indian J Gastroenterol Country: India |
Other Details:
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Languages: eng Pagination: S25-7 Citation Subset: IM |
Affiliation:
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Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109, USA. kdm@po.cwru.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Hepatic Encephalopathy
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physiopathology* Humans Hypertension, Portal / physiopathology*, surgery Portal Pressure / physiology* Portal System / physiopathology* Portasystemic Shunt, Surgical* Portasystemic Shunt, Transjugular Intrahepatic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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