Document Detail

Interplay of defective excitation-contraction coupling, energy starvation, and oxidative stress in heart failure.
MedLine Citation:
PMID:  22626245     Owner:  NLM     Status:  In-Data-Review    
In chronic heart failure, maladaptive remodeling of the left ventricle (LV) with systolic and diastolic dysfunction underlies the inability of the heart to pump sufficient blood to supply the body with blood and oxygen. Three integral aspects of this maladaptive LV remodeling are (1) defects in excitation-contraction (EC) coupling, particularly of cellular Ca(2+) and Na(+) homeostasis; (2) an energetic deficit; and (3) oxidative stress. Although these three aspects are often investigated separately from each other, their close and dynamic interplay are increasingly recognized. Central to this novel approach are mitochondria, which are the main source for cellular ATP, but also for reactive oxygen species, and their function is critically regulated by Ca(2+) and Na(+). Here, we review recent advances in our understanding of how maladaptive changes of EC coupling can contribute to the energetic deficit and oxidative stress, which may initiate a vicious cycle leading to progressive cardiac dysfunction.
Michael Kohlhaas; Christoph Maack
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  21     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2012-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-73     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg/Saar, Germany.
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