| Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery. | |
| | |
MedLine Citation:
|
PMID: 20965572 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNFα) and interleukin 1-beta (IL-1β) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNFα promoter polymorphisms (-G308A and -G238A), a single IL-1β polymorphism (+C3954T), vaginal microbial findings, and risk of preterm delivery. Data were from the Pregnancy Outcomes and Community Health (POUCH) Study (n=777 term and n=230 preterm deliveries). Vaginal smears collected at mid-pregnancy (15-27 weeks gestation) were scored according to Nugent's criteria. A Nugent score of ≥ 4 was modeled as the cut-point for intermediate and positive BV. Logistic regression was used to estimate odds ratios for associations among independent covariates (vaginal flora, genotype) and preterm delivery. Results showed that women with a Nugent score of≥ 4 and the TNFα -238 A/G or A/A were at increased risk of delivering preterm (race/ethnicity adjusted OR 2.6, 95% CI 1.2, 5.8). The p-value for the genotype and Nugent score interaction=0.02. This study points to one more example of a potential gene-environment interaction in a preterm delivery pathway. Future tests of this finding will determine the robustness of these results. |
| | |
Authors:
|
Nicole M Jones; Claudia Holzman; Karen H Friderici; Katherine Jernigan; Hwan Chung; Julia Wirth; Rachel Fisher |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2010-10-20 |
Journal Detail:
|
Title: Journal of reproductive immunology Volume: 87 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2011-05-20 Revised Date: 2011-12-21 |
Medline Journal Info:
|
Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 82-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Epidemiology, B601 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA. njones@epi.msu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cohort Studies Cytokines Female Genotype Humans Interleukin-1beta / genetics Polymorphism, Single Nucleotide Pregnancy Pregnancy Outcome Premature Birth / etiology*, genetics, microbiology Risk Factors Tumor Necrosis Factor-alpha / genetics* Vagina / microbiology Vaginosis, Bacterial / complications* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD034543-03/HD/NICHD NIH HHS; R01 HD034543-04/HD/NICHD NIH HHS; R01 HD034543-05A1/HD/NICHD NIH HHS; R01 HD034543-06/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07S1/HD/NICHD NIH HHS; R01 HD034543-08/HD/NICHD NIH HHS; R01 HD34543-01/HD/NICHD NIH HHS; T32 HD046377/HD/NICHD NIH HHS; T32 HD046377-05/HD/NICHD NIH HHS; T32 HD046377-06/HD/NICHD NIH HHS; U01 DP000143-02/DP/NCCDPHP CDC HHS |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Interleukin-1beta; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fusion protein of TLR5-ligand and allergen potentiates activation and IL-10 secretion in murine myel...
Next Document: Perceived threat mediates the relationship between psychosis proneness and aggressive behavior.