Document Detail

Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery.
MedLine Citation:
PMID:  20965572     Owner:  NLM     Status:  MEDLINE    
Recent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNFα) and interleukin 1-beta (IL-1β) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNFα promoter polymorphisms (-G308A and -G238A), a single IL-1β polymorphism (+C3954T), vaginal microbial findings, and risk of preterm delivery. Data were from the Pregnancy Outcomes and Community Health (POUCH) Study (n=777 term and n=230 preterm deliveries). Vaginal smears collected at mid-pregnancy (15-27 weeks gestation) were scored according to Nugent's criteria. A Nugent score of ≥ 4 was modeled as the cut-point for intermediate and positive BV. Logistic regression was used to estimate odds ratios for associations among independent covariates (vaginal flora, genotype) and preterm delivery. Results showed that women with a Nugent score of≥ 4 and the TNFα -238 A/G or A/A were at increased risk of delivering preterm (race/ethnicity adjusted OR 2.6, 95% CI 1.2, 5.8). The p-value for the genotype and Nugent score interaction=0.02. This study points to one more example of a potential gene-environment interaction in a preterm delivery pathway. Future tests of this finding will determine the robustness of these results.
Nicole M Jones; Claudia Holzman; Karen H Friderici; Katherine Jernigan; Hwan Chung; Julia Wirth; Rachel Fisher
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2010-10-20
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  87     ISSN:  1872-7603     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-05-20     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Epidemiology, B601 West Fee Hall, Michigan State University, East Lansing, MI 48824, USA.
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MeSH Terms
Cohort Studies
Interleukin-1beta / genetics
Polymorphism, Single Nucleotide
Pregnancy Outcome
Premature Birth / etiology*,  genetics,  microbiology
Risk Factors
Tumor Necrosis Factor-alpha / genetics*
Vagina / microbiology
Vaginosis, Bacterial / complications*
Young Adult
Grant Support
R01 HD034543-03/HD/NICHD NIH HHS; R01 HD034543-04/HD/NICHD NIH HHS; R01 HD034543-05A1/HD/NICHD NIH HHS; R01 HD034543-06/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07/HD/NICHD NIH HHS; R01 HD034543-07S1/HD/NICHD NIH HHS; R01 HD034543-08/HD/NICHD NIH HHS; R01 HD34543-01/HD/NICHD NIH HHS; T32 HD046377/HD/NICHD NIH HHS; T32 HD046377-05/HD/NICHD NIH HHS; T32 HD046377-06/HD/NICHD NIH HHS; U01 DP000143-02/DP/NCCDPHP CDC HHS
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1beta; 0/Tumor Necrosis Factor-alpha

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