| Interplay between intrinsic noise and the stochasticity of the cell cycle in bacterial colonies. | |
| | |
MedLine Citation:
|
PMID: 20513389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Herein we report on the effects that different stochastic contributions induce in bacterial colonies in terms of protein concentration and production. In particular, we consider for what we believe to be the first time cell-to-cell diversity due to the unavoidable randomness of the cell-cycle duration and its interplay with other noise sources. To that end, we model a recent experimental setup that implements a protein dilution protocol by means of division events to characterize the gene regulatory function at the single cell level. This approach allows us to investigate the effect of different stochastic terms upon the total randomness experimentally reported for the gene regulatory function. In addition, we show that the interplay between intrinsic fluctuations and the stochasticity of the cell-cycle duration leads to different constructive roles. On the one hand, we show that there is an optimal value of protein concentration (alternatively an optimal value of the cell cycle phase) such that the noise in protein concentration attains a minimum. On the other hand, we reveal that there is an optimal value of the stochasticity of the cell cycle duration such that the coherence of the protein production with respect to the colony average production is maximized. The latter can be considered as a novel example of the recently reported phenomenon of diversity induced resonance. |
| | |
Authors:
|
Oriol Canela-Xandri; Francesc Sagués; Javier Buceta |
Related Documents
:
|
14967829 - Angiotensin ii and cell cycle regulation. 18790559 - Ppargamma-independent antitumor effects of thiazolidinediones. 12628359 - Cell-cycle dysregulation and anticancer therapy. 21457099 - Organ-specific scaffolds for in vitro expansion, differentiation and organization of pr... 8366059 - Density fluctuation during the cell cycle in the defective vacuolar morphology mutants ... 17141209 - The anaphase-promoting complex is required in both dividing and quiescent cells during ... 11968019 - Chromatin of trypanosoma cruzi: in situ analysis revealed its unusual structure and nuc... 7954399 - Discovery of short, 3'-cholesterol-modified dna duplexes with unique antitumor cell act... 416589 - Cell population kinetics in the epithelium of the colon of the male rat. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biophysical journal Volume: 98 ISSN: 1542-0086 ISO Abbreviation: Biophys. J. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-01 Completed Date: 2010-09-02 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 0370626 Medline TA: Biophys J Country: United States |
Other Details:
|
Languages: eng Pagination: 2459-68 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Computer Simulation and Modeling Laboratory, Parc Científic de Barcelona, Barcelona, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Algorithms Bacteria / cytology* Bacterial Proteins / metabolism Cell Cycle Cell Division Gene Expression Regulation Models, Biological* Protein Biosynthesis Stochastic Processes Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phase-dependent effects of stimuli locked to oscillatory activity in cultured cortical networks.
Next Document: Synchronization of circadian oscillation of phosphorylation level of KaiC in vitro.