Document Detail


Interplay between glutathione-S-transferase and glucose-6-phosphate dehydrogenase in neonatal cord blood.
MedLine Citation:
PMID:  9395837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three hundred neonatal cord blood samples were collected from two major cities in Jordan and assayed for glutathione-S-transferase (GST), glutathione, and glucose-6-phosphate dehydrogenase (G6PD). A significant positive correlation between the levels of G6PD and GST activities was detected. When the G6PD activity decreased, the GST activity declined. A similar concurrent decrease in the concentration of reduced glutathione was also observed. When the samples were divided into males and female samples, some significant variations in the levels of the two enzymes were observed. Female samples exhibited higher G6PD and GST activities as compared with male samples. Moreover, the incidence of severe and moderate G6PD deficiencies was higher in male as compared with female samples. Analyses of the samples for total bilirubin, red blood cells, hematocrit, and hemoglobin were also performed, and slight nonsignificant variations were noted.
Authors:
A A Hunaiti; M al-Shareef
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study    
Journal Detail:
Title:  Biology of the neonate     Volume:  72     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1997  
Date Detail:
Created Date:  1998-02-03     Completed Date:  1998-02-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Yarmouk University, Irbid, Jordan. hunaiti@matah.edu.jo
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MeSH Terms
Descriptor/Qualifier:
Bilirubin / blood
Female
Fetal Blood / enzymology*
Glucosephosphate Dehydrogenase / blood*,  metabolism
Glucosephosphate Dehydrogenase Deficiency / blood,  epidemiology
Glutathione / blood
Glutathione Transferase / blood*
Humans
Incidence
Infant, Newborn
Male
Sex Factors
Chemical
Reg. No./Substance:
635-65-4/Bilirubin; 70-18-8/Glutathione; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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