Document Detail

Interplay between endocannabinoids, steroids and cytokines in the control of human reproduction.
MedLine Citation:
PMID:  18426505     Owner:  NLM     Status:  MEDLINE    
The use of marijuana, which today is the most used recreational drug, has been demonstrated to affect adversely reproduction. Marijuana smokers, both men and women, show impaired fertility, owing to defective signalling pathways, aberrant hormonal regulation, or wrong timing during embryo implantation. Anandamide (N-arachidonoylethanolamine, AEA) and 2-arachidonoylglycerol (2-AG) mimic Delta(9)-tetrahydrocannabinol (THC), the psychoactive principle of Cannabis sativa, by binding to both the brain-type (CB(1)) and the spleen-type (CB(2)) cannabinoid receptors. These 'endocannabinoids' exert several actions either in the central nervous system or in peripheral tissues, and are metabolised by specific enzymes that synthesise or hydrolyse them. In this review, we shall describe the elements that constitute the endocannabinoid system (ECS), in order to put in a better perspective the role of this system in the control of human fertility, both in females and males. In addition, we shall discuss the interplay between ECS, sex hormones and cytokines, which generates an endocannabinoid-hormone-cytokine array critically involved in the control of human reproduction.
N Battista; N Pasquariello; M Di Tommaso; M Maccarrone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  20 Suppl 1     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-22     Completed Date:  2008-07-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  82-9     Citation Subset:  IM    
Department of Biomedical Sciences, University of Teramo, Teramo, Italy.
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MeSH Terms
Cannabinoids / pharmacology
Cytokines / physiology*
Endocannabinoids / metabolism,  physiology*
Fertility / drug effects,  physiology
Gonadal Steroid Hormones / pharmacology,  physiology
Gonads / metabolism
Models, Biological
Receptors, Cannabinoid / metabolism
Reproduction / drug effects,  physiology*
Steroids / physiology*
Reg. No./Substance:
0/Cannabinoids; 0/Cytokines; 0/Endocannabinoids; 0/Gonadal Steroid Hormones; 0/Receptors, Cannabinoid; 0/Steroids

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