Document Detail

Interplay between differentiation and cell cycle arrest at G1 in phorbol diester-treated human myelocytic leukemia cells.
MedLine Citation:
PMID:  8219109     Owner:  NLM     Status:  MEDLINE    
The cell cycle arrest at G1 of myelocytic leukemia cells by incubation with phorbol diesters was examined in HL-60 cells and more mature THP-1 cells. We found: (1) induction of phenotypic parameters of differentiation prior to G1 arrest; (2) a long induction period in HL-60 cells compared to zero in THP-1 cells; and (3) strong inhibition of G1 arrest with a protein kinase C inhibitor in THP-1 cells. We conclude, from these lines of evidence and some additional information, that differentiation induces G1 arrest. At present, the most plausible causative molecule is Mac-1.
T Oda; K Kitajima; T Hirano; N Shimizu; H Utiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of hematology     Volume:  58     ISSN:  0925-5710     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-12-20     Completed Date:  1993-12-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Life Science Group, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
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MeSH Terms
Cell Differentiation / drug effects
G1 Phase / drug effects
Leukemia, Myeloid, Acute / pathology*
Phorbol 12,13-Dibutyrate / pharmacology
Phorbol Esters / pharmacology*
Tetradecanoylphorbol Acetate / pharmacology
Tumor Cells, Cultured / drug effects,  pathology
Reg. No./Substance:
0/Phorbol Esters; 16561-29-8/Tetradecanoylphorbol Acetate; 37558-16-0/Phorbol 12,13-Dibutyrate

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