| Interplay between differentiation and cell cycle arrest at G1 in phorbol diester-treated human myelocytic leukemia cells. | |
| | |
MedLine Citation:
|
PMID: 8219109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The cell cycle arrest at G1 of myelocytic leukemia cells by incubation with phorbol diesters was examined in HL-60 cells and more mature THP-1 cells. We found: (1) induction of phenotypic parameters of differentiation prior to G1 arrest; (2) a long induction period in HL-60 cells compared to zero in THP-1 cells; and (3) strong inhibition of G1 arrest with a protein kinase C inhibitor in THP-1 cells. We conclude, from these lines of evidence and some additional information, that differentiation induces G1 arrest. At present, the most plausible causative molecule is Mac-1. |
| | |
Authors:
|
T Oda; K Kitajima; T Hirano; N Shimizu; H Utiyama |
Related Documents
:
|
3019049 - Influence of hormone treatment applied or begun in different phases of the cell cycle o... 3873499 - Separate control of b lymphocyte early activation and proliferation in response to anti... 11054109 - Effect of cadmium on the relationship between replicative and repair dna synthesis in s... 10697579 - Effect of vitamins a, c and e on normal and hpv-immortalized human oral epithelial cell... 7692289 - Induction of chromatid breaks and tetraploidy in chinese hamster ovary cells by treatme... 20716119 - Cutting edge: chk1 directs senescence and mitotic catastrophe in recovery from g₂ che... 18514349 - Inhibition of west nile virus replication in cells stably transfected with vector-based... 9010339 - Membrane binding sites and non-genomic effects of estrogen in cultured human pre-osteoc... 18037969 - Neoplastic transformation of human small airway epithelial cells induced by arsenic. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of hematology Volume: 58 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 1993 Aug |
Date Detail:
|
Created Date: 1993-12-20 Completed Date: 1993-12-20 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 125-8 Citation Subset: IM |
Affiliation:
|
Life Science Group, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Differentiation
/
drug effects G1 Phase / drug effects Humans Leukemia, Myeloid, Acute / pathology* Phorbol 12,13-Dibutyrate / pharmacology Phorbol Esters / pharmacology* Tetradecanoylphorbol Acetate / pharmacology Tumor Cells, Cultured / drug effects, pathology |
| Chemical | |
Reg. No./Substance:
|
0/Phorbol Esters; 16561-29-8/Tetradecanoylphorbol Acetate; 37558-16-0/Phorbol 12,13-Dibutyrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A patient with Tn syndrome associated with myelodysplastic syndrome showed abnormal glycophorin B.
Next Document: Okadaic acid biologically mimics the role of calcium/phospholipid dependent kinase inhibitors in the...