Document Detail

Interplay between FOXO, TOR, and Akt.
MedLine Citation:
PMID:  21440577     Owner:  NLM     Status:  MEDLINE    
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
Nissim Hay
Related Documents :
24482227 - Tyrosine phosphorylation of wasp by hck regulates macrophage function.
22955057 - Rhoa localization with caveolin-1 regulates vascular contractions to serotonin.
23469147 - The maize ost1 kinase homolog phosphorylates and regulates the maize snac1-type transcr...
24471457 - Antimycotics suppress the malassezia extract-induced production of cxc chemokine ligand...
18388497 - Persistent factor viii-dependent factor x activation on endothelial cells is independen...
1312047 - Receptor tyrosine kinases.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-01
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1813     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2011-12-20     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1965-70     Citation Subset:  IM    
Copyright Information:
2011 Elsevier B.V. All rights reserved.
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Feedback, Physiological*
Forkhead Transcription Factors / metabolism*
Models, Biological
Proteins / metabolism*
Proto-Oncogene Proteins c-akt / metabolism*
Ribosomal Protein S6 Kinases, 70-kDa / metabolism
Grant Support
AG 025953/AG/NIA NIH HHS; CA 016927/CA/NCI NIH HHS; CA 090764/CA/NCI NIH HHS; R01 AG016927/AG/NIA NIH HHS; R01 AG025953/AG/NIA NIH HHS; R01 CA090764/CA/NCI NIH HHS
Reg. No./Substance:
0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Proteins; 0/mechanistic target of rapamycin complex 1; EC protein, human; EC Proteins c-akt; EC Protein S6 Kinases, 70-kDa; EC protein S6 kinase, 70kD, polypeptide 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative study on the song behavior and song control nuclei in male and female Mongolian larks (M...
Next Document:  Glucose deprivation is associated with Chk1 degradation through the ubiquitin-proteasome pathway and...