Document Detail


Interplay between FOXO, TOR, and Akt.
MedLine Citation:
PMID:  21440577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.
Authors:
Nissim Hay
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-01
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1813     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2011-12-20     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1965-70     Citation Subset:  IM    
Copyright Information:
2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, IL 60607, USA. nhay@uic.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Feedback, Physiological*
Forkhead Transcription Factors / metabolism*
Humans
Models, Biological
Proteins / metabolism*
Proto-Oncogene Proteins c-akt / metabolism*
Ribosomal Protein S6 Kinases, 70-kDa / metabolism
Grant Support
ID/Acronym/Agency:
AG 025953/AG/NIA NIH HHS; CA 016927/CA/NCI NIH HHS; CA 090764/CA/NCI NIH HHS; R01 AG016927/AG/NIA NIH HHS; R01 AG025953/AG/NIA NIH HHS; R01 CA090764/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/FOXO1 protein, human; 0/Forkhead Transcription Factors; 0/Proteins; 0/mechanistic target of rapamycin complex 1; EC 2.7.11.1/AKT1 protein, human; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 2.7.11.1/Ribosomal Protein S6 Kinases, 70-kDa; EC 2.7.11.1/ribosomal protein S6 kinase, 70kD, polypeptide 1
Comments/Corrections

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