| Interplay Between the Acute Inflammatory Response and Heart Rate Variability in Healthy Human Volunteers. | |
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MedLine Citation:
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PMID: 21451444 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The autonomic nervous system (ANS) and the inflammatory response are intimately linked. Heart rate variability (HRV) analysis is a widely employed method to assess cardiac ANS activity, and changes in HRV indices may correlate with inflammatory markers. Here, we investigated whether baseline HRV predicts the acute inflammatory response to endotoxin. Second, we investigated whether the magnitude of the inflammatory response correlated with HRV alterations.40 healthy volunteers received a single intravenous bolus of 2 ng/kg endotoxin (lipopolysaccharide, LPS, derived from E coli O:113). Of these, 12 healthy volunteers were administered LPS again two weeks later. HRV was determined at baseline (just prior to LPS administration) and hourly thereafter until 8 hours post-LPS. Plasma cytokine levels were determined at various time-points.Baseline HRV indices did not correlate with the magnitude of the LPS-induced inflammatory response. Despite large alterations in HRV following LPS administration, the extent of the inflammatory response did not correlate with the magnitude of HRV changes. In subjects that were administered LPS twice, inflammatory cytokines were markedly attenuated following the second LPS administration, while LPS-induced HRV alterations were similar.HRV indices do not predict the acute inflammatory response in a standardized model of systemic inflammation. While the acute inflammatory response results in HRV changes, no correlations with inflammatory cytokines were observed. Therefore, the magnitude of endotoxemia-related HRV changes do not reflect the extent of the inflammatory response. |
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Authors:
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Matthijs Kox; Bart P Ramakers; Jan C Pompe; Johannes G van der Hoeven; Cornelia W Hoedemaekers; Peter Pickkers |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, internal mail 685, Geert Grooteplein 10, 6500 HB, Nijmegen, The Netherlands. |
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