Document Detail

Interpersonal traits change as a function of disease type and severity in degenerative brain diseases.
MedLine Citation:
PMID:  21172858     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Different degenerative brain diseases result in distinct personality changes as a result of divergent patterns of brain damage; however, little is known about the natural history of these personality changes throughout the course of each disease.
OBJECTIVE: To investigate how interpersonal traits change as a function of degenerative brain disease type and severity.
METHODS: Using the Interpersonal Adjective Scales, informant ratings of retrospective premorbid and current scores for dominance, extraversion, warmth and ingenuousness were collected annually for 1 to 4 years on 188 patients (67 behavioural variant frontotemporal dementia (bvFTD), 40 semantic dementia (SemD), 81 Alzheimer's disease (AD)) and 65 older healthy controls. Using random coefficient models, interpersonal behaviour scores at very mild, mild or moderate-to-severe disease stages were compared within and between patient groups.
RESULTS: Group-level changes from premorbid personality occurred as a function of disease type and severity, and were apparent even at a very mild disease stage (Clinical Dementia Rating=0.5) for all three diseases. Decreases in interpersonal traits were associated with emotional affiliation (ie, extraversion, warmth and ingenuousness) and more rigid interpersonal behaviour differentiated bvFTD and SemD patients from AD patients.
CONCLUSIONS: Specific changes in affiliative interpersonal traits differentiate degenerative brain diseases even at a very mild disease stage, and patterns of personality change differ across bvFTD, SemD and AD with advancing disease. This study describes the typical progression of change of interpersonal traits in each disease, improving the ability of clinicians and caregivers to predict and plan for symptom progression.
Marc Sollberger; John Neuhaus; Robin Ketelle; Christine M Stanley; Victoria Beckman; Matthew Growdon; Jung Jang; Bruce L Miller; Katherine P Rankin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-15
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  82     ISSN:  1468-330X     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-10     Completed Date:  2011-08-19     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  732-9     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / psychology
Analysis of Variance
Data Interpretation, Statistical
Disease Progression
Extraversion (Psychology)
Frontotemporal Lobar Degeneration / psychology
Interpersonal Relations*
Linear Models
Middle Aged
Neurodegenerative Diseases / psychology*
Neuropsychological Tests
Psychiatric Status Rating Scales
Grant Support
5-K23-AG021606-02/AG/NIA NIH HHS; AG19724-01A1/AG/NIA NIH HHS; GCRC-M01-RR00079/RR/NCRR NIH HHS; K23 AG021606/AG/NIA NIH HHS; K23 AG021606-01/AG/NIA NIH HHS; K23 AG021606-02/AG/NIA NIH HHS; P01 AG019724/AG/NIA NIH HHS; P01 AG019724-01A1/AG/NIA NIH HHS; P01 AG019724-03/AG/NIA NIH HHS; PPG P01-AG1972403/AG/NIA NIH HHS; R01 AG029577/AG/NIA NIH HHS; R01 AG029577-01A2/AG/NIA NIH HHS

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