Document Detail

Interobserver variation in the diagnosis of adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix.
MedLine Citation:
PMID:  12828609     Owner:  NLM     Status:  MEDLINE    
To examine the interobserver agreement level of the histological diagnosis of adenoma malignum (ADM), 52 proliferative endocervical glandular lesions were evaluated independently by four observers (A to D), each of whom is in charge of gynecological pathology at a different hospital. The correlation of diagnosis by each observer with patient outcome was also examined for 19 of these lesions. When the diagnoses were categorized into benign lesions including hyperplasias, ADM, and common types of adenocarcinoma, consistent diagnoses among all observers were achieved for only 12 lesions (23%), with a slight level of interobserver agreement (kappa=0.115). The points of disagreement were as follows: (i) whether proliferative endocervical glandular lesions preserving lobular structures were diagnosed as benign or as ADM; and (ii) whether proliferative endocervical glandular lesions with a discrete area of obvious adenocarcinoma were diagnosed as ADM or as common-type adenocarcinoma. The mortality rates of patients with ADM diagnosed by observers A, B, C, and D were 60% (3 of 5), 25% (3 of 12), 14% (1 of 7), and 13% (2 of 15), respectively. Therefore, ADM diagnosed by observers A and B was frequently lethal, whereas ADM diagnosed by observers C and D was mostly non-lethal and might contain benign lesions. The diagnosis of ADM covered various spectra of proliferative endocervical glandular lesions among the observers. Disagreement in the diagnosis was suggested to derive largely from the absence of consensus criteria for differential diagnosis among benign hyperplastic lesions, ADM, and common adenocarcinoma, and from differences in the observers' interpretations about cellular atypia and invasion.
Hitoshi Tsuda; Yoshiki Mikami; Tsunehisa Kaku; Futoshi Akiyama; Tadashi Hasegawa; Satoshi Okada; Isamu Hayashi; Takahiro Kasamatsu
Related Documents :
16931119 - Why oral histopathology suffers inter-observer variability on grading oral epithelial d...
14744729 - Expression of the high mobility group proteins hmgi(y) correlates with malignant progre...
12809869 - Cytologic detection of human papillomavirus dna in normal male urethral samples.
11781519 - Proliferative activity of benign and neoplastic endocervical epithelium and correlation...
16683389 - Hpv 6-positive giant keratoacanthoma in an immunocompetent patient.
12775989 - Low-grade malignant eccrine spiradenoma with systemic metastases.
3006649 - Progressive blindness caused by metastatic occult signet-ring cell gastric carcinoma.
7900609 - Intracoronary ultrasound-defined plaque composition: computer-aided plaque characteriza...
2614239 - Symptomatic mucosal cysts of the maxillary sinus: antroscopic treatment.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  53     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-27     Completed Date:  2004-03-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  440-9     Citation Subset:  IM    
Department of Pathology II, National Defense Medical College, Tokorozawa, Saitama, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / diagnosis*,  mortality,  surgery
Cervical Intraepithelial Neoplasia / diagnosis*,  mortality,  surgery
Hyperplasia / pathology
Observer Variation
Precancerous Conditions / diagnosis*,  mortality,  surgery
Survival Rate
Uterine Cervical Neoplasms / diagnosis*,  mortality,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expression of inducible nitric oxide synthase in thyroid neoplasms: immunohistochemical and molecula...
Next Document:  Hepatocellular carcinoma with osteoclast-like giant cells: possibility of osteoclastogenesis by hepa...