Document Detail

Interobserver variability of magnetic resonance angiography in the diagnosis of carotid stenosis--effect of observer experience.
MedLine Citation:
PMID:  11942364     Owner:  NLM     Status:  MEDLINE    
Magnetic resonance angiography (MRA) for determining the degree of carotid stenosis prior to carotid endarterectomy is attractive because it does not have the high morbidity associated with conventional intra-arterial angiography. We assessed the interobserver variability in the estimation of the degree of stenosis amongst observers of different experience. In a prospective study, consecutive patients with transient ischaemic attacks and symptomatic tight carotid stenosis shown by Doppler ultrasound underwent conventional intra-arterial angiography and 2-D and 3-D time-of-flight MRA of the carotid bifurcations. The films of the processed MRA images were reviewed blind to other clinical and imaging data by eight observers of different levels of experience and coded for the presence and degree of stenosis. The stenosis on intra-arterial angiography was used as the reference standard. There was considerable variability between observers for estimation of the degree of stenosis on MRA. The observers' accuracy ranged from 41% (student) to 79% (experienced). From these estimations, excluding those of the student, it could be seen that up to 23% of patients who would have had an endarterectomy based on MRA should not have done so according to angiography, and up to 33% of patients who should have had an endarterectomy according to angiography would have inappropriately missed having an endarterectomy based on MRA results. Observer reliability of MRA processed images is not good, even in experienced hands. Using the source images and views of the circle of Willis might improve the accuracy, but a further study is required to assess this.
J M Wardlaw; S C Lewis; D A Collie; R Sellar
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroradiology     Volume:  44     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-04-10     Completed Date:  2002-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  126-32     Citation Subset:  IM    
Department of Clinical Neurosciences, University of Edinburgh, Western General Hospitals NHS Trust, UK.
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MeSH Terms
Carotid Artery, Internal / pathology*,  radiography*,  surgery
Carotid Stenosis / diagnosis*,  epidemiology*,  surgery
Endarterectomy, Carotid
Magnetic Resonance Angiography*
Observer Variation
Prospective Studies
Comment In:
Neuroradiology. 2002 Oct;44(10):868-9; author reply 870   [PMID:  12528674 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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