Document Detail

Interobserver variability on the histopathologic diagnosis of cutaneous melanoma and other pigmented skin lesions.
MedLine Citation:
PMID:  8648377     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the interobserver agreement on the diagnosis and classification of cutaneous melanoma. MATERIALS AND METHODS: A set of 140 slides of cutaneous melanoma, including a small subset of benign pigmented skin lesions, were circulated to four experienced histopathologists. The kappa statistic for multiple ratings per subject was calculated using the method described by Fleiss. RESULTS: The kappa value on the diagnosis of cutaneous melanoma versus benign lesions was 0.61. There was some discordance on the diagnosis in 37 of 140 cases (26%). For the histopathologic classification of cutaneous melanoma, the highest kappa values were attained for Breslow thickness (kappa = 0.76) and presence of ulceration (kappa = 0.87). The agreement was generally poor for other histologic features, such as level of dermal invasion (kappa = 0.38), presence of regression (kappa = 0.27), and lymphocytic infiltration (kappa = 0.27). CONCLUSION: Our study suggests considerable disagreement among pathologists on the diagnosis of melanoma versus other pigmented lesions. Tumor thickness and presence of ulceration are the most reproducible histologic features of cutaneous melanoma.
R Corona; A Mele; M Amini; G De Rosa; G Coppola; P Piccardi; M Fucci; P Pasquini; T Faraggiana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  14     ISSN:  0732-183X     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-07-25     Completed Date:  1996-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1218-23     Citation Subset:  IM    
Servizio di Epidemiologia Clinica e Servizio di Istopatologia, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero E Cura A Carattere Scientifico, Rome, Italy.
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MeSH Terms
Melanoma / classification,  pathology*
Observer Variation*
Reproducibility of Results
Retrospective Studies
Skin Diseases / pathology
Skin Neoplasms / classification,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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