Document Detail

Interobserver Reproducibility Study of the Histological Patterns of Primary Lung Adenocarcinoma With Emphasis on a More Complex Glandular Pattern Distinct From the Typical Acinar Pattern.
MedLine Citation:
PMID:  24477939     Owner:  NLM     Status:  Publisher    
The newly proposed International Association for the Study of Lung Cancer, American Thoracic Society, and European Respiratory Society (IASLC/ATS/ERS) classification of lung adenocarcinoma has emphasized the prognostic significance of histological subtyping. In this study, 2 surgical pathologists reevaluated 49 consecutive cases of invasive primary pulmonary adenocarcinomas; histological subtyping was performed according to the IASLC/ATS/ERS classification. The 2 reviewers agreed on the predominant pattern in 23 out of 32 independently reviewed cases (71.9%, k = 0.628, 95% confidence interval = 0.442-0.815). Postconsensus, a complex glandular pattern consisting of fused, closely packed glands and cribriform architecture was identified in 9 of 49 (18%) cases. This pattern has a strong association with lymphovascular invasion (78%; P = .0091), high mitotic activity (89%), and higher tumor stage (78%). Frequent association of complex glandular pattern with poor prognostic factors and its overlap with acinar pattern warrant a more detailed description of this pattern in the classification system and a large-scale study to evaluate its prognostic significance.
Congli Wang; Heba Y Durra; Yajue Huang; Varsha Manucha
Related Documents :
11795459 - Baló's concentric sclerosis: surviving normal myelin in a patient with a relapsing-remi...
13460739 - Multiple myeloma; a review of 26 cases.
10894599 - Multiple esophageal rings: an association with eosinophilic esophagitis: case report an...
12592089 - A case of unilateral, systematized linear hair follicle nevi associated with epidermal ...
16354259 - Agminated spitz nevi: report of a child with a unique dermatomal distribution.
16215569 - Low grade multiple myeloma that presented as a labial swelling -- a case report.
15996619 - Cryptococcal osteomyelitis in a 20-year-old male with sarcoidosis.
6109669 - Uretero-urinary fistulae in obstetrics: report of three cases.
6860059 - Fulminant hepatitis associated with disulfiram. report of a case.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-29
Journal Detail:
Title:  International journal of surgical pathology     Volume:  -     ISSN:  1940-2465     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Amputation Neuroma Growing Intravascularly Into a Thrombus.
Next Document:  Establishment of a short-term, in vivo screening method for detecting chemicals with juvenile hormon...