Document Detail

International study of factors affecting human chromosome translocations.
MedLine Citation:
PMID:  18337160     Owner:  NLM     Status:  MEDLINE    
Chromosome translocations in peripheral blood lymphocytes of normal, healthy humans increase with age, but the effects of gender, race, and cigarette smoking on background translocation yields have not been examined systematically. Further, the shape of the relationship between age and translocation frequency (TF) has not been definitively determined. We collected existing data from 16 laboratories in North America, Europe, and Asia on TFs measured in peripheral blood lymphocytes by fluorescence in situ hybridization whole chromosome painting among 1933 individuals. In Poisson regression models, age, ranging from newborns (cord blood) to 85 years, was strongly associated with TF and this relationship showed significant upward curvature at older ages versus a linear relationship (p<0.001). Ever smokers had significantly higher TFs than non-smokers (rate ratio (RR)=1.19, 95% confidence interval (CI), 1.09-1.30) and smoking modified the effect of age on TFs with a steeper age-related increase among ever smokers compared to non-smokers (p<0.001). TFs did not differ by gender. Interpreting an independent effect of race was difficult owing to laboratory variation. Our study is three times larger than any pooled effort to date, confirming a suspected curvilinear relationship of TF with age. The significant effect of cigarette smoking has not been observed with previous pooled studies of TF in humans. Our data provide stable estimates of background TF by age, gender, race, and smoking status and suggest an acceleration of chromosome damage above age 60 and among those with a history of smoking cigarettes.
Alice J Sigurdson; Mina Ha; Michael Hauptmann; Parveen Bhatti; Radim J Sram; Olena Beskid; E Janet Tawn; Caroline A Whitehouse; Carita Lindholm; Mimako Nakano; Yoshiaki Kodama; Nori Nakamura; Irena Vorobtsova; Ursula Oestreicher; Günther Stephan; Lee C Yong; Manfred Bauchinger; Ernst Schmid; Hai Won Chung; Firouz Darroudi; Laurence Roy; Phillipe Voisin; Joan F Barquinero; Gordon Livingston; David Blakey; Isamu Hayata; Wei Zhang; Chunyan Wang; L Michelle Bennett; L Gayle Littlefield; Alan A Edwards; Ruth A Kleinerman; James D Tucker
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2008-02-02
Journal Detail:
Title:  Mutation research     Volume:  652     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-08-19     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  112-21     Citation Subset:  IM    
Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
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MeSH Terms
Age Factors
Aged, 80 and over
Child, Preschool
Chromosome Painting
Ethnic Groups
In Situ Hybridization, Fluorescence
Infant, Newborn
International Cooperation
Middle Aged
North America
Risk Factors
Sex Factors
Translocation, Genetic*
Grant Support
P01 CA059431-060001/CA/NCI NIH HHS; P01 CA059431-070001/CA/NCI NIH HHS; P01 CA059431-08/CA/NCI NIH HHS; P01 CA059431-080001/CA/NCI NIH HHS; P01 CA059431-08S10001/CA/NCI NIH HHS; Y1 CP 9012/CP/NCI NIH HHS; Y2 AI 5077/AI/NIAID NIH HHS; Y3 CO 5117/CO/NCI NIH HHS

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