Document Detail

International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources.
MedLine Citation:
PMID:  20855440     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recurrent wheezing (RW) during the first year of life is a major cause of respiratory morbidity worldwide, yet there are no studies on its prevalence at an international level. A study was undertaken to determine the prevalence of RW in infants during their first year of life in affluent and non-affluent localities.
METHODS: This international population-based study was performed in random samples of infants aged 12-15 months from 17 centres in Latin America and Europe. It uses a validated questionnaire answered by parents at the primary care health clinics where infants attend for growth/development monitoring and/or vaccine administration.
RESULTS: Among the 30,093 infants surveyed, 45.2% (95% CI 44.7% to 45.8%) had at least one episode of wheezing and 20.3% (95% CI 19.8% to 20.7%) had RW. The mean prevalence of RW in Latin American and European centres was 21.4% (95% CI 20.9% to 21.9%) and 15.0% (95% CI 14.0% to 15.9%), respectively (p<0.001). There was significant morbidity associated with RW in terms of severe episodes (59.4%), visits to the emergency department (71.1%) and hospital admissions (26.8%); 46.1% used inhaled corticosteroids.
CONCLUSIONS: The prevalence of RW in infants during the first year of life is high and varies between localities. A significant proportion of infants progress to a more severe condition which results in high use of health resources (visits to emergency department and hospitalisations). The prevalence of RW is lower and less severe in European than in Latin American centres, suggesting there is a higher risk for the disease in developing areas.
Javier Mallol; Luis García-Marcos; Dirceu Solé; Paul Brand;
Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2010-09-20
Journal Detail:
Title:  Thorax     Volume:  65     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-22     Completed Date:  2010-11-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  1004-9     Citation Subset:  IM    
Department of Pediatric Respiratory Medicine, Hospital El Pino, University of Santiago de Chile, Santiago, Chile.
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MeSH Terms
Asthma / epidemiology
Cross-Sectional Studies
Disease Progression
Drug Utilization / statistics & numerical data
Europe / epidemiology
Health Services / utilization*
Latin America / epidemiology
Respiratory Sounds*
Respiratory System Agents / administration & dosage
Respiratory Tract Diseases / drug therapy,  epidemiology*
Respiratory Tract Infections / epidemiology
Reg. No./Substance:
0/Respiratory System Agents
Manuel Baeza-Bacab / ; Alvaro Madeiro Leite / ; Olívia Costa Bessa / ; Elaine Xavier Prestes / ; Emanuel Sarinho / ; Décio Medeiros / ; Paulo Camargos / ; María Jussara Fernández-Fontes / ; Wilson Rocha / ; Dirceu Sole / ; Caroline Della Bianca / ; Nelson Rosario Herberto Chong / ; Gilberto B Fischer / ; Eduardo Cepeda / ; Oscar Aldrey / ; Arnaldo Capriles / ; Javier Mallol / ; Viviana Aguirre / ; Alejandro Gallardo / ; Mario Calvo / ; Luis García-Marcos / ; Antonela Martínez-Torres / ; Virginia Pérez-Fernández / ; Carlos González-Díaz / ; Andrés González Hermosa / ; Angel López-Silvarrey Varela / ; María Morales Suárez-Varela / ; Paul L P Brand / ; Chantal A N Visser /

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