Document Detail


International multicentre study of indapamide in the treatment of essential arterial hypertension.
MedLine Citation:
PMID:  7033949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 1600 patients with essential arterial hypertension was recruited from 10 countries, and treated with indapamide according to a common protocol. 703 subjects who completed the protocol were analysed, from whom 644 were followed for 3 months, and the remainder (all from Belgium) up to 10 months. The group of 644 showed a highly significant drop in erect and supine blood pressures after one month, and this was maintained after 3 months treatment. The percentage of responders (normalization of diastolic pressure, or drop of at least 30 mmHg) was 64% after 3 months. The Belgian group maintained their reductions in pressure at 6 and 10 months. Serum potassium showed a modest drop, but remained within normal limits: other biochemical values were virtually unchanged. Some side effects were noted, but none was serious. It is concluded that indapamide is a first line treatment for essential arterial hypertension.
Authors:
J Passeron; N Pauly; J Desprat
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  57 Suppl 2     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2009-10-22    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antihypertensive Agents / therapeutic use*
Clinical Trials as Topic
Diuretics / therapeutic use*
Female
Humans
Hypertension / drug therapy*
Indapamide / therapeutic use*
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Diuretics; 26807-65-8/Indapamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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