Document Detail


International multicenter term PROM study: evaluation of predictors of neonatal infection in infants born to patients with premature rupture of membranes at term. Premature Rupture of the Membranes.
MedLine Citation:
PMID:  9757963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our objective was to determine significant predictors for the development of neonatal infection in infants born to patients with premature rupture of membranes at term. STUDY DESIGN: Multivariate analysis was used to determine the significant predictors of neonatal infection in infants born to women with premature rupture of the membranes who were enrolled in the Term PROM Study. In a randomized, controlled trial, the Term PROM Study recently compared induction of labor with expectant management for premature rupture of membranes at term. RESULTS: The following variables were identified as independent predictors of neonatal infection: clinical chorioamnionitis (odds ratio 5.89, P < .0001), positive maternal group B streptococcal status (vs negative or unknown, odds ratio 3.08, P < .0001), 7 to 8 vaginal digital examinations (vs 0 to 2, odds ratio 2.37, P = .04), 24 to < 48 hours from membrane rupture to active labor (vs < 12 hours, odds ratio 1.97, P = .02), > or = 48 hours from membrane rupture to active labor (vs < 12 hours, odds ratio 2.25, P = .01), and maternal antibiotics before delivery (odds ratio 1.63, P = .05). CONCLUSIONS: Among infants born to patients with premature rupture of membranes at term, clinical chorioamnionitis and maternal colonization with group B streptococci are the most important predictors of subsequent neonatal infection.
Authors:
P G Seaward; M E Hannah; T L Myhr; D Farine; A Ohlsson; E E Wang; E Hodnett; K Haque; J A Weston; G Ohel
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  179     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-10-22     Completed Date:  1998-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  635-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Centre for Research in Women's Health, and University of Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chorioamnionitis / complications,  microbiology
Delivery, Obstetric*
Evaluation Studies as Topic
Female
Fetal Membranes, Premature Rupture / complications*
Forecasting
Humans
Incidence
Infant, Newborn
Infant, Newborn, Diseases* / epidemiology
Infection / complications*,  epidemiology
International Cooperation
Pregnancy
Streptococcal Infections / complications
Streptococcus agalactiae

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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