Document Detail

International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck.
MedLine Citation:
PMID:  24710845     Owner:  NLM     Status:  Publisher    
Background: This study aimed to characterize the incidence, pattern of spread and prognostic correlation of nerve invasion (NI) in patients with adenoid cystic carcinoma (ACC). Methods: Using 3 different pathological categories of perineural invasion, intraneural invasion and perineural inflammation, we investigated the prognostic value of NI in a total of 495 ACC from 9 international patient cohorts with median follow up 90 months (range 12-288). Results: With Of 239(48%) patients with NI, 174(73%) had perineural invasion, 65(27%) intraneural invasion and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p=0.008, HR=1.8, 95% CI=0.07-3.7) and intraneural invasion (p<0.001, HR=5.9, 95%CI=0.8-12.3) as independent prognostic markers for both overall and disease-specific survival, but not of distant metastases. Conclusions: While perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patient with head and neck ACC. Head Neck, 2014.
Moran Amit; Yoav Binenbaum; Leonor Trejo-Leider; Kanika Sharma; Ramer Naomi; Ramer Ilana; Agbetoba Abib; Brett Miles; Xinjie Yang; Delin Lei; Bjoerndal Kristine; Godballe Christian; Mücke Thomas; Wolff Klaus-Dietrich; André M Eckardt; Copelli Chiara; Enrico Sesenna; Palmer Frank; Ganly Ian; Snehal Patel; Ziv Gil
Related Documents :
16924365 - Extensive bone metastases from basal cell carcinoma of the eye.
19112615 - Patterns and predictors of early recurrence in postmenopausal women with estrogen recep...
20731845 - Biological characteristics and treatment outcomes of metastatic or recurrent neuroendoc...
15995505 - Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: ...
455585 - Vindesine in the treatment of breast cancer.
17236695 - Sense of humor and survival among a county cohort of patients with end-stage renal fail...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-7
Journal Detail:
Title:  Head & neck     Volume:  -     ISSN:  1097-0347     ISO Abbreviation:  Head Neck     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Wiley Periodicals, Inc., A Wiley Company.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Yield of Cardiac Magnetic Resonance Imaging as an Adjunct to Echocardiography in Young Infants With ...
Next Document:  N-heterocyclic carbene (NHC)-modulated Pd/Cu cocatalyzed three-component synthesis of 2,6-diarylquin...