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An International Series on Abdominal Radical Trachelectomy: 101 Patients and 28 Pregnancies.
MedLine Citation:
PMID:  22914213     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Abdominal radical trachelectomy (ART) is a type C resection (uterine vessels ligated at origin from the hypogastric vessels). Questions arise as to whether fertility is maintained after ART, particularly when uterine vessels are sacrificed. We report an international series on ART to describe fertility and oncologic outcomes. METHODS: Databases at 3 institutions were queried to identify patients planned for ART from 1999 to 2011. Clinical and demographic data were gathered. RESULTS: One hundred one patients underwent ART. Mean age was 31 years (range, 19-43 years). Histologic classifications were adenocarcinoma (n = 54), squamous cell carcinoma (n = 40), adenosquamous carcinoma (n = 6), and clear cell carcinoma (n = 1). Twenty patients (20%) required conversion to hysterectomy (10 margins and 10 nodes). Eight patients underwent completion hysterectomy owing to the following: positive margins on final pathology (n = 3), patient's choice (n = 4), or recurrence (n = 1). Postoperatively, 20 patients (20%) received adjuvant chemotherapy and/or radiation (4 final pathology margins and 16 nodes). Four patients (4%) had recurrence and lived 22 to 35 months after diagnosis. Of the 70 women who had neither hysterectomy nor adjuvant therapy, 38 (54%) attempted pregnancy and 28 (74%) achieved pregnancy. Thirty-one pregnancies resulted in 16 (52%) third trimester deliveries. Six patients are currently pregnant with outcomes pending. CONCLUSIONS: These data demonstrate that ART preserves fertility and maintains excellent oncologic outcomes. Most women (74%) attempting pregnancy after ART are able to achieve pregnancy and deliver in the third trimester (52%). Preservation of the uterine vasculature is not necessary for fertility; obstetrical outcomes are similar to those of the historical vaginal radical trachelectomy cohorts.
Authors:
Stephanie L Wethington; David Cibula; Linda R Duska; Leslie Garrett; Christine H Kim; Dennis S Chi; Yukio Sonoda; Nadeem R Abu-Rustum
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  22     ISSN:  1525-1438     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1251-1257     Citation Subset:  -    
Affiliation:
*Department of Surgery, Division of Gynecology, Memorial Sloan-Kettering Cancer Center, New York, NY; †Gynecologic Oncology Center, Department of Obstetrics and Gynecology, General University Hospital, First Medical Faculty, Charles University, Prague, Czech Republic; ‡Department of Obstetrics and Gynecology, Thornton Gynecologic Oncology Service, University of Virginia Health System, Charlottesville, VA; §Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and ∥Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY.
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