Document Detail


International Federation of Clinical Chemistry standardization project for the measurement of lipoprotein(a). Phase I. Evaluation of the analytical performance of lipoprotein(a) assay systems and commercial calibrators.
MedLine Citation:
PMID:  9702949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A secondary reference material for lipoprotein(a) is required to standardize the measurement of lipoprotein(a) in clinical laboratories worldwide. Towards this aim, the International Federation of Clinical Chemistry Working Group for the Standardization of Lipoprotein(a) Assays has initiated a standardization project involving a total of 33 diagnostic company and clinical chemistry laboratories from 12 countries. In Phase 1, the analytical performance of 40 lipoprotein(a) assay systems was evaluated by testing sera and manufactured lipoprotein(a) calibrator materials for precision, linearity, and parallelism. Twenty test systems were nonoptimized according to the results for a pooled serum, which tested nonlinear in 16 systems and imprecise in 4. Acceptable analytical properties and harmonization of lipoprotein(a) values were shown by some commercial calibrators, suggesting their possible use as reference materials. This study highlights the problems that currently occur for lipoprotein(a) measurement in existing assay systems.
Authors:
J R Tate; N Rifai; K Berg; R Couderc; F Dati; G M Kostner; I Sakurabayashi; A Steinmetz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical chemistry     Volume:  44     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-08-20     Completed Date:  1998-08-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1629-40     Citation Subset:  IM    
Affiliation:
Department of Chemical Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. tatej@health.qld.gov.au
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MeSH Terms
Descriptor/Qualifier:
Calibration
Data Interpretation, Statistical
Humans
International Cooperation
Laboratory Techniques and Procedures / standards*
Lipoprotein(a) / blood,  standards*
Quality Control
Reference Standards
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Lipoprotein(a)

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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