| International Federation of Clinical Chemistry standardization project for the measurement of lipoprotein(a). Phase I. Evaluation of the analytical performance of lipoprotein(a) assay systems and commercial calibrators. | |
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MedLine Citation:
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PMID: 9702949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A secondary reference material for lipoprotein(a) is required to standardize the measurement of lipoprotein(a) in clinical laboratories worldwide. Towards this aim, the International Federation of Clinical Chemistry Working Group for the Standardization of Lipoprotein(a) Assays has initiated a standardization project involving a total of 33 diagnostic company and clinical chemistry laboratories from 12 countries. In Phase 1, the analytical performance of 40 lipoprotein(a) assay systems was evaluated by testing sera and manufactured lipoprotein(a) calibrator materials for precision, linearity, and parallelism. Twenty test systems were nonoptimized according to the results for a pooled serum, which tested nonlinear in 16 systems and imprecise in 4. Acceptable analytical properties and harmonization of lipoprotein(a) values were shown by some commercial calibrators, suggesting their possible use as reference materials. This study highlights the problems that currently occur for lipoprotein(a) measurement in existing assay systems. |
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Authors:
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J R Tate; N Rifai; K Berg; R Couderc; F Dati; G M Kostner; I Sakurabayashi; A Steinmetz |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical chemistry Volume: 44 ISSN: 0009-9147 ISO Abbreviation: Clin. Chem. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-20 Completed Date: 1998-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421549 Medline TA: Clin Chem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1629-40 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia. tatej@health.qld.gov.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Calibration Data Interpretation, Statistical Humans International Cooperation Laboratory Techniques and Procedures / standards* Lipoprotein(a) / blood, standards* Quality Control Reference Standards Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Lipoprotein(a) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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