| An International Consensus Survey of Diagnostic Criteria for Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis. | |
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MedLine Citation:
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PMID: 21285158 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To identify candidate diagnostic criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) using international consensus formation through a Delphi questionnaire survey. METHODS: A questionnaire listing 28 clinical, laboratory, and histopathologic features of MAS elicited by literature review was sent to 505 pediatric rheumatologists worldwide. Respondents were asked to select the 10 features that they felt were most important and useful in the diagnosis of MAS, and to order the 10 selected features by assigning the number 10 to the most important, and ending with 1 as the least important. RESULTS: The response rate was 46% (232 physicians from 47 countries). The items selected by more than 50% of respondents were, in order of frequency, falling platelet count, hyperferritinemia, evidence of macrophage hemophagocytosis in the bone marrow, increased liver enzymes, falling leukocyte count, persistent continuous fever ≥ 38°C, falling erythrocyte sedimentation rate, hypofibrinogenemia, and hypertriglyceridemia. CONCLUSION: Our process led to identification of features that were felt to be most important as candidate diagnostic criteria for MAS by a large sample of international pediatric rheumatologists. |
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Authors:
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Sergio Davì; Alessandro Consolaro; Dinara Guseinova; Angela Pistorio; Nicolino Ruperto; Alberto Martini; Randy Q Cron; Angelo Ravelli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: The Journal of rheumatology Volume: - ISSN: 0315-162X ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini, Genova; Università degli Studi di Genova, Genova, Italy; and Children's Hospital of Alabama and University of Alabama at Birmingham, Birmingham, Alabama, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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