Document Detail


Internally standardized method for the determination of nalbuphine in human plasma by means of high performance liquid chromatography with electrochemical coulometric detection.
MedLine Citation:
PMID:  3245848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A high performance liquid chromatographic method with internal analogue standardization and electrochemical detection for the determination of nalbuphine in human plasma is described. Using 3 ml plasma the lower limit of detection is below 50 pg/ml, during the routine assay the limit of determination can be fixed at about 250-300 pg/ml. The calibration curve is linear in the range between 0.163-65 ng/l, the recovery rate from plasma exceeds 80%. The method was successfully applied in several pharmacokinetic studies.
Authors:
N Wetzelsberger; P W Lücker; W Erking
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  38     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1768-71     Citation Subset:  IM    
Affiliation:
Institut für klinische Pharmakologie Bobenheim, Grünstadt, Fed. Rep. of Germany.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid
Electrochemistry
Humans
Indicators and Reagents
Morphinans / blood*
Nalbuphine / blood*,  pharmacokinetics
Naltrexone / pharmacology
Quality Control
Reference Standards
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Morphinans; 16590-41-3/Naltrexone; 20594-83-6/Nalbuphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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