| Internally standardized method for the determination of nalbuphine in human plasma by means of high performance liquid chromatography with electrochemical coulometric detection. | |
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MedLine Citation:
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PMID: 3245848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high performance liquid chromatographic method with internal analogue standardization and electrochemical detection for the determination of nalbuphine in human plasma is described. Using 3 ml plasma the lower limit of detection is below 50 pg/ml, during the routine assay the limit of determination can be fixed at about 250-300 pg/ml. The calibration curve is linear in the range between 0.163-65 ng/l, the recovery rate from plasma exceeds 80%. The method was successfully applied in several pharmacokinetic studies. |
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Authors:
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N Wetzelsberger; P W Lücker; W Erking |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 38 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-06-02 Completed Date: 1989-06-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 1768-71 Citation Subset: IM |
Affiliation:
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Institut für klinische Pharmakologie Bobenheim, Grünstadt, Fed. Rep. of Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, High Pressure Liquid Electrochemistry Humans Indicators and Reagents Morphinans / blood* Nalbuphine / blood*, pharmacokinetics Naltrexone / pharmacology Quality Control Reference Standards |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Morphinans; 16590-41-3/Naltrexone; 20594-83-6/Nalbuphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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