Document Detail

Internal sphincterotomy reduces postoperative pain after Milligan Morgan haemorrhoidectomy.
Jump to Full Text
MedLine Citation:
PMID:  19852840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Over the last few years, there has been increasing attention on surgical procedures to treat haemorrhoids. The Milligan-Morgan haemorrhoidectomy is still one of the most popular surgical treatments of haemorrhoids. The aim of the present work is to assess postoperative pain, together with other early and late complications, after Milligan-Morgan haemorrhoidectomy as we could observe in our experience before and after performing an internal sphincterotomy.
METHODS: from January 1980 to May 2007, we operated 850 patients, but only 699 patients (median age 53) were included in the present study because they satisfied our inclusion criteria. The patients were divided into two groups: all the patients operated on before 1995 (group A); all the patients operated on after 1995 (group B). Since 1995 an internal sphincterotomy of about 1 cm has been performed at the end of the procedure. The data concerning the complications of these two groups were compared. All the patients received a check-up at one and six months after operation and a telephone questionnaire three years after operation to evalue medium and long term results.
RESULTS: after one month 507 patients (72.5%) did not have any postoperative complication. Only 192 patients (27.46%) out of 699 presented postoperative complication and the most frequent one (23.03%) was pain. The number of patients who suffered from postoperative pain decreased significantly when performing internal sphincterotomy, going from 28.8% down to 10.45% (chi(2): 10,880; p = 0,0001); 95% Confidence Interval (CI) 24.7 to 28.9 (group A) and 10.17 to 10.72 (group B). In 51 cases (7.29%) urinary retention was registered. Six cases of bleeding (0.85%) were registered. Medium and long term follow up did not show any difference among the two groups.
CONCLUSION: internal sphincterotomy: reduces significantly pain only in the first postoperative period, but not in the medium-long term follow up; does not increase the incidence of continence impairment when performed; does not influence the incidence of the other postoperative complications especially as regard medium and long term results.
Authors:
Giuseppe Diana; Giovanni Guercio; Bianca Cudia; Calogero Ricotta
Publication Detail:
Type:  Journal Article     Date:  2009-10-24
Journal Detail:
Title:  BMC surgery     Volume:  9     ISSN:  1471-2482     ISO Abbreviation:  BMC Surg     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-26     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  100968567     Medline TA:  BMC Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  16     Citation Subset:  IM    
Affiliation:
Università degli Studi di Palermo- Dipartimento di Chirurgia Generale, d'Urgenza e dei Trapianti d'Organo- Via Liborio Giuffrè n degrees 5- 90100- Palermo- Italy. gadiana@unipa.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anal Canal / surgery*
Digestive System Surgical Procedures / methods
Female
Hemorrhoids / surgery*
Humans
Male
Middle Aged
Pain, Postoperative* / prevention & control
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): BMC Surg
ISSN: 1471-2482
Publisher: BioMed Central
Article Information
Download PDF
Copyright © 2009 Diana et al; licensee BioMed Central Ltd.
open-access: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received Day: 26 Month: 3 Year: 2009
Accepted Day: 24 Month: 10 Year: 2009
collection publication date: Year: 2009
Electronic publication date: Day: 24 Month: 10 Year: 2009
Volume: 9First Page: 16 Last Page: 16
ID: 2774293
Publisher Id: 1471-2482-9-16
PubMed Id: 19852840
DOI: 10.1186/1471-2482-9-16

Internal sphincterotomy reduces postoperative pain after Milligan Morgan haemorrhoidectomy
Giuseppe Diana1 Email: gadiana@unipa.it
Giovanni Guercio1 Email: giangu@unipa.it
Bianca Cudia1 Email: biancacudia@unipa.it
Calogero Ricotta1 Email: calogeroricotta@yahoo.com
1Università degli Studi di Palermo- Dipartimento di Chirurgia Generale, d'Urgenza e dei Trapianti d'Organo- Via Liborio Giuffrè n° 5- 90100- Palermo- Italy

Background

Over the last few years, there has been increasing attention on surgical procedures to treat haemorrhoids. Several comparative studies have been performed to evaluate the procedures already available to treat second, third, and fourth-degree haemorrhoids, and new surgical techniques, such as, for instance, haemorrhoidectomy with Harmonic scalpel® [1-3] and Ligasure™[4], doppler guided haemorrhoidal plexus ligation[5,6] and the stapled haemorrhoidopexy [7-13].

The most recent publications provide data on the efficacy, the results and complications from medium and long-term studies carried out on ample case series [14-20]. Despite the support offered by different authors, none of these techniques proved to reduce pain at such levels to be unanimously chosen [11].

Today, however, the Milligan-Morgan haemorrhoidectomy is still one of the most popular surgical treatments of haemorrhoids

The aim of the present work is to assess postoperative pain, together with other early and late complications, after Milligan-Morgan haemorrhoidectomy as we could observe in our experience before and after performing an internal sphincterotomy.


Methods

Since January 1980, patients undergoing haemorrhoid treatment in our General Surgery unit have been involved in a research study on post-haemorrhoidectomy complications. Until May 2007, there were 850 operated patients in total. However, 151 patients were not included in the study because of the reasons listed in table 1.

The operated patients available for the present study are 699, median age 53 (range 16-78) (Table 2).

The patients underwent surgical treatment when they had at least one of the symptoms listed in table 3.

In 31 cases none of the mentioned symptoms and complications were present, but the patients insisted to undergo surgery.

Before the procedure, all patients underwent proctoscopy.

The operations were carried out under general anaesthesia and infiltration of pudendal nerves with 15 ml bupivacaine with 1:200000 adrenaline. Further 5 ml of the same solution were used to dissect the haemorrhoidal nodules from the internal sphincter. Except 27 patients, who had a considerable rectal mucosal prolapse and were treated with stapled haemorrhoidopexy, all the patients underwent the same procedure, i.e. the Milligan-Morgan haemorrhoidectomy

We removed the haemorrhoidal nodule by performing an upside-down V-shaped incision on the anal dermis, without widening the surgical wound while approaching the sphincters. This was done in order to maintain ample mucous membrane bridges. Possible secondary nodules were removed trough submucosa. Furthermore we performed these technical arrangements:

• Park's suspensor ligament is not removed with the haemorrhoidal nodule (so as not to include the ligament in the transfixed stitch);

• coagulation with electrotome on the anal sphincters is avoided;

• the edges of the residual surgical wound have to be as sharp as possible.

Since 1995 an internal sphincterotomy of about 1 cm was performed at the end of the procedure, as was the case for 220 patients. We chose permanent surgical sphincterotomy, instead of temporary medical one, because at that time it was the only effective procedure in reducing postoperative sphincter spasm.

The patients were divided into two groups: patients operated on before (group A) and after 1995 (group B). The data concerning the complications of this group of patients (group B) were compared with those regarding the patients operated on before sphincterotomy (group A). No antibiotic prophylaxis has ever been administered.

On the basis of literature data and our clinical experience, it was possible to register the early endpoints (table 4).

When discharged, the patients were invited to have a check-up after one and six months from the operation, so as to assess our endpoints (table 5).

In particular, we evalued pain using the visual analog scale (VAS). We considered pain as severe when: VAS > 5; patients needed administration of ketorolac three times or more a day; pain did not disappear after the third postoperative day.

Three years after the operation the patients were contacted again by phone to check the recurrence of haemorrhoids and/or other disorders and, where possible, to have a further check-up.

The study received the approval from the University School of Medicine of Palermo Ethics Committee and was in compliance with the Helsinki Declaration.


Results

Of all 699 patients who underwent haemorrhoidectomy, 507 patients (72.5%) did not have any postoperative complication. Table 5 shows the postoperative data concerning 192 patients (27.46%) out of 699.

Pain stands as the most frequent complication (23.03%). These patients had to be administered ketorolac more than three times a day. However, pain tended to disappear spontaneously between the third and the fifth postoperative day. In 19 cases (2.7%) pain persisted for more than ten days and was accompanied by the onset of an anal fissure. The number of patients who suffered from postoperative pain decreased significantly when performing internal sphincterotomy, going from 28.8% down to 10.45% (χ2 : 10,880; p = 0,0001); 95% Confidence Interval (CI) 24.7 to 28.9 (group A) and 10.17 to 10.72 (group B). We did not register any clinical impairment of continence in the two groups of patients.

In 51 cases (7.29%) urinary retention was registered (in 37 cases this complication was associated with pain or oedema or fever). The problem was solved by applying a catheter. The sphincterotomy did not reduce such complication significantly.

Six cases of bleeding (0.85%) were registered: four early cases, between the first and the second postoperative day, and two late cases. Despite the various efforts made, haemostasis was achieved by performing a transfixed stitch. The two cases of late haemorrhage showed more serious consequences. One patient had a serious anaemia with haemoglobinemia levels of 7.5 g/dl. The other patient, on the tenth day, did not show serious anaemia thanks to a further early procedure. However, he had to be transferred to intensive care, due to the onset of aspiration pneumonia.

One month after the operation 697 patients had a check-up: in 221 of these patients (31.61%) healing had not been achieved yet, whereas 5 cases (0.71%) had already been affected by stenosis. Finally, 13 patients (1.87%) complained that they sometimes were not able to control gas (8 cases) or also liquid faeces. There was not any statistically difference as regard the impairment of continence in the two groups of patients (table 4).

Six months after the operation 694 patients were evalued: 477 had the operation before 1995, whereas the remaining 217 patients had the operation after 1995. Twenty-three patients (3.31%) were diagnosed as having a fissure on one of the haemorrhoidectomy beds. The internal sphincterotomy did not reduce significantly this complication, which affected 2.59% of cases. It is worth emphasising that 21 patients out of the 23 patients who were affected by a fissure had had pain as an immediate postoperative complication. Three other patients were affected by stenosis, whereas patients suffering from incontinence decreased to nine (1.30%) and only occasionally had gas incontinence.

After three years, the results were studied on 532 patients out of the 699 patients who had been operated and answered the questionnaire. Thirteen patients (2.45%) had a recurrence and 47 patients (8.83%) reported that they occasionally experienced bleeding, though there was no evidence of haemorrhoidal recurrence. In 38 patients skin tags were found.


Discussion

Drawing on our experience, we evalued the complications arising after surgical procedures to treat haemorrhoids and in particular we wanted to assess postoperative pain and other complications.

Among the complications, the most frequent one is surely the onset of severe pain, whose incidence in our data is in line with literature data [10-21] including studies on the use of a stapling device.

In this respect, it is worth considering the importance of performing anal divulsion/internal sphincterotomy to prevent postoperative pain, as already highlighted in several multi-centre clinical trials [22,23]. Some authors, instead, assess that the internal sphincterotomy does not influence the incidence of postoperative pain [24,25]. Sometimes pain may persist over time after cicatrisation of wounds. In most of these cases, the cause should be attributed to the formation of an anal fissure on the groove of one of the excised peduncles.

Continence-related disorders include the possible onset of various degrees of incontinence or of costiveness. Incontinence occurring after a procedure of low ligature is rare and transitory, as it resolves by itself within 3-5 days after the operation. Moreover, it is usually not above grade C Browning-Parks[26].

In our experience, the incidence of incontinence was lower than the levels reported by Graviè et al. [17] at check-up after one month (1.86% vs. 8.8%) and after six months (1.29% vs. 8.8%). Incontinence is more frequent after a Whitehead procedure, and it is also for this reason that this technique is not popular and it is indicated for selected patients under the supervision of an expert surgeon [27].

In reviewing 400 patients treated by Montorsi [28], the same author found a proportion of anal fissures amounting to 5%. In such cases, the treatment consists in regularizing the alvus and, in particularly resistant cases, performing an anal divulsion or an internal sphincterotomy.

The cases of urinary retention observed in our study (7.30%) are less than those indicated by Toyonaga T. et al. [29,30] (21.9%), and they are near the data provided by Chik B. et al. [31] (7.77%) in a study on stapled haemorroidopexy. This complication affects more male subjects, mostly aged between 40 and 60 years.

Postoperative bleeding is a particularly important complication in treating haemorroids due to its frequency, which vary between 0.6% and 10% [31,32] depending on the study considered. Sometimes bleeding may be alarming, because it may cause anaemia very rapidly in patients.

The causes of such bleeding are not easily explained: in some cases it should be attributed to falling off of an scar due to electrocoagulation, whereas in other cases it is due to the lack of a thrombus, its expulsion or its dissolution, concomitant with the falling or reabsorption of the transfixed stitch.

Haemorrhoidal recurrence stands at around 2-8% [17]. On the other hand, in the past the proportion of recurrence used to be around 14%, as already pointed out by Goligher [33]. However, one system to prevent this from occurring is to perform subcutaneous removal of these nodules.

Long-term outcomes of haemorrhoidectomy procedures include the onset of malformations of the anal canal, with varying degrees of seriousness up to cases of stenosis. In our experience, the incidence of anal stenosis is very low (0.43%). This is probably due to the fact that we avoid widening the residual surgical wound.

As regards long term recurrence (three years), in our data we found an incidence of 2.45%, which is in line with literature data and lower than methods that are considered more efficacious, such as, for instance, stapled haemorroidopexy, which is reported to have a higher incidence[34].


Conclusion

The types and frequency of immediate, medium and long-term complications we could observe following a Milligan-Morgan haemorrhoidectomy are in line or, for some variables, even less than those described in the literature.

The present paper shows how, according to our experience, the internal sphincterotomy: reduces significantly pain only in the first postoperative period, but not in the medium-long term follow up; does not increase the incidence of continence impairment when performed; does not influence the incidence of the other postoperative complications especially as regard medium and long term results.

Our study highlights how results can be improved by implementing some technical arrangements, which expert proctologists are able to carry out. This way, in terms of results and complications, the Milligan-Morgan haemorrhoidectomy is similar to other techniques, which are recently become popular because of the lower degree of pain referred by their advertising.


Competing interests

The authors declare that they have no competing interests.


Authors' contributions

GD conceived of the study, participated in the coordination of the study and operated on the patients of the study. GG participated in the design, performed the statistical analysis and operated on the patients. BC helped in the statistical analysis and helped in the draft of the manuscript. CR participated in the collection of the data and in the draft of the manuscript. All authors read and approved the final manuscript.


Authors' informations

GD: Full Professor of Surgery at the School of Medicine of the University of Palermo, Director of the Unit of General and Geriatric Surgery at the University Hospital Policlinico "P.Giaccone".

GG: researcher at the School of Medicine of the University of Palermo, resident surgeon at the Department of General, Urgency and Transplant Surgery.

BC: researcher at the School of Medicine of the University of Palermo.

CR: fellow in Digestive and Endoscopic Surgery at the School of Medicine of the University of Palermo.


Pre-publication history

The pre-publication history for this paper can be accessed here:


References
Khan S,Pawlak SE,Eggenberger JC,et al. Surgical treatment of hemorrhoids: prospective, randomised trial comparing closed hemorrhoidectomy and the harmonic scalpel technique of excisional hemorrhoidectomyDis Colon Rectum 2001;44:845–849. [pmid: 11391146] [doi: 10.1007/BF02234706]
Ramadan E,Vishne T,Dreznik Z. Harmonic scalpel hemorrhoidectomy: preliminary results of a new alternative methodTech Coloproctol 2002;6:89–92. [pmid: 12402052] [doi: 10.1007/s101510200019]
Tan JJ,Seow-Choen F. Prospective, randomised trial comparing diathermy and Harmonic scalpel hemorrhoidectomyDis Colon Rectum 2001;44:677–679. [pmid: 11357028] [doi: 10.1007/BF02234565]
Palazzo FF,Francis DL,Clifton FA. Randomized clinical trial of Ligasure™versus open haemorrhoidectomyBr J Surg 2002;89:154–157. [pmid: 11856126]
Scheyer M,Antonietti E,Rollinger G,Mall H,Arnold S. Doppler-guided artery ligationAm J Surg 2006;191:89–93. [pmid: 16399113] [doi: 10.1016/j.amjsurg.2005.10.007]
Morinaga K,Hasuda K,Ikeda T. A novel therapy for internal hemorrhoids. Ligation of the haemorrhoidal artery with a newly devised instrument (Moricorn) in conjiunction with a Doppler flow meterAm J Gastroenterol 1995;90:610–613. [pmid: 7717320]
Longo A. Trattamento della malattia emorroidaria mediante correzione del prolasso mucoso rettale con suturatrice circolare. Tecnica originaleArchivio ed Atti della Società Italiana di Chirurgia 1998;2°:233–246. Roma
Mehigan BJ,Monson JR,Hartley JE. Stapling procedure for haemorrhoids versus Milligan-Morgan haemorrhoidectomy: randomised controlled trialLancet 2000;355:782–5. [pmid: 10711925] [doi: 10.1016/S0140-6736(99)08362-2]
YH, Ho;F, Sew-Choen;C, Tsang;KW, Fu.Randomized trial assessing anal sphincter injiuries after stapled haemorrhoidectomyBr J Surg 2001;88:1449–1455. [pmid: 11683739] [doi: 10.1046/j.0007-1323.2001.01899.x]
Cheetham MJ,Mortensen NJM,Nystro PO,Kamm MA,Phillips RKS. Persistent pain and faecal urgency after stapled haemorrhoidectomyLancet 2000;356:730–733. [pmid: 11085693] [doi: 10.1016/S0140-6736(00)02632-5]
Seow-Choen F. Stapled haemorrhoidectomy: pain or gainBr J Surg 2001;88:1–3. [pmid: 11136303] [doi: 10.1046/j.1365-2168.2001.01651.x]
Ganio E,Altomare F,Gabrielli F,Milito G,Canuti S. Prospective randomized multicentre trial comparing stapled with open haemorrhoidectomyBr J Surg 2001;88:669–674. [pmid: 11350437] [doi: 10.1046/j.0007-1323.2001.01772.x]
Maw A,Eu KW,Sew-Choen F. Retroperitoneal sepsis complicating stapled hemorrhoidectomyDis Colon Rectum 2002;45:826–828. [pmid: 12072637] [doi: 10.1007/s10350-004-6304-z]
Ng K-H,Ho KS,Ooi BS,Tang CL,Eu KW. Experience of 3711 stapled haemorrhoidectomy operationBr J Surg 2006;93:226–230. [pmid: 16323166] [doi: 10.1002/bjs.5214]
Lan P,Wu X,Zhou X,Wang J,Zhang L. The safety and efficacy of stapled haemorrhoidectomy in the treatment of haemorrhoids: a systematic review and meta-analysis of ten randomised control trialInt J Colorectal Dis 2006;21:172–178. [pmid: 15971065] [doi: 10.1007/s00384-005-0786-6]
Kanellos I,Zacharakis E,D Kanellos,Pramateftakis MG,Tsachalis T,Betsis D. Long-term results after stapled haemorrhoidopexy for third-degree haemorrhoidsTech Coloproctol 2006;10:47–4. [pmid: 16528483] [doi: 10.1007/s10151-006-0250-9]
Graviè JF,Lehur PA,Huten N,Papillon M,Fantoli M,Descottes B,Pessaux P,Arnaud JP. Stapled haemorrhoidopexy versus Milligan Morgan haemorrhoidectomyAnn Surg 2005;242:29–35. [pmid: 15973098] [doi: 10.1097/01.sla.0000169570.64579.31]
Fueglistaler P,Guenin MO,Montali I,Kern B,Peterli R,Von Flüe M,Ackermann C. Long term results after stapled haemorrhoidopexy: high patient satisfaction despite frequent postoperative symptomsDis Colon Rectum 2006;50:204–212. [pmid: 17180255] [doi: 10.1007/s10350-006-0768-y]
Lomanto D,Katara AN. Stapled haemorrhoidopexy for prolapsed haemorrhoids: short and long term experienceAsian J Surg 2007;30:29–33. [pmid: 17337368]
Jayaraman S,Colquhoun PH,Malthaner RA. Stapled haemorrhoidopexy is associated with a higher long-term recurrence rate of internal haemorrhoids compared with conventional excisional haemorrhoid surgeryDis Colon Rectum 2007;50:1297–305. [pmid: 17665254] [doi: 10.1007/s10350-007-0308-4]
Herold A,Kirsch JJ. Pain after stapled haemorrhoidectomyLancet 2000;356:2187. [pmid: 11191562] [doi: 10.1016/S0140-6736(05)67258-3]
Kanellos I,Zacharakis E,Christoforidis E,Angelopoulos S,Kanellos D,Pramateftakis MG,Betsis D. Usefulness of lateral internal sphincterotomy in reducing postoperative pain after open hemorrhoidectomyWorld J Surg 2005;29:464–8. [pmid: 15770383] [doi: 10.1007/s00268-004-7432-2]
Galizia G,Lieto E,Imperatore V,Pelosio L,Castellano P. The usefulness of lateral internal sphincterotomy combined with hemorrhoidectomy in the treatment of hemorrhoids: a randomized prospective studyG Chir 2000;21:127–134. [pmid: 10810824]
Khubchandani IT. Internal sphincterotomy with hemorrhoidectomy does not relieve pain: a prospective, randomized studyDis Colon Rectum 2002;45:1452–7. [pmid: 12432291] [doi: 10.1007/s10350-004-6450-3]
Pescatori M,Favetta U,Navarra L. Anal pressures after hemorrhoidectomyInt J Colorectal Dis 1998;13:149. [pmid: 9689567] [doi: 10.1007/s003840050154]
Browning GG,Parks AG. Postanal repair for neuropathic faecal incontinence: Correlation of clinical result and anal canal pressuresBr J Surg 1983;70:101–104. [pmid: 6824891] [doi: 10.1002/bjs.1800700216]
Maria G,Alfonsi G,Nigro C,Brisinda G. Whitehead's hemorrhoidectomy. A useful surgical procedure in selected casesTech Coloproctol 2001;5:93–6. [pmid: 11862565] [doi: 10.1007/s101510170006]
Montorsi M,Rebuffat C,Rosati R,Bona S,Fumagalli U,Massari M. Hemorrhoids: current therapeutic directionsMinerva Chir 1990;45:1–3. [pmid: 2186295]
Toyonaga T,Matsushima M,Sogawa N,Jiang SF,Matsumura N,Shimojima Y,Tanaka Y,Suzuki K,Masuda J,Tanaka M. Postoperative urinary retention after surgery for benign anorectal disease: potential risk factors and strategy for preventionInt J Colorectal Surg 2006;21:676–82. [doi: 10.1007/s00384-005-0077-2]
Pescatori M. Urinary retention after anorectal operationsDis Colon Rectum 1999;42:964. [pmid: 10411448] [doi: 10.1007/BF02237112]
Chik B,Law WL,Choi HK. Urinary retention after haemorrhoidectomy: Impact of stapled haemorrhoidectomyAsian J Surg 2006;29:233–7. [pmid: 17098654]
Pescatori M. Closed vs. open hemorrhoidectomy: associated sphincterotomy and postoperative bleedingDis Colon Rectum 2000;43:1174–5. [pmid: 10950021] [doi: 10.1007/BF02236571]
Goligher JC. Surgery of the Anus, Rectum and Colon (5). 19845. London: Bailliere Tindall;
Nisar PJ,Acheson AG,Neal KR,Scholefield JH. Stapled hemorrhoidopexy compared with conventional hemorrhoidectomy: Systematic review of randomized, controlled trialsDis Colon Rectum 2004;47:1837–1845. [pmid: 15622575] [doi: 10.1007/s10350-004-0679-8]

Tables
[TableWrap ID: T1] Table 1 

Patients excluded, because they did not fit the inclusion criteria or they had additional proctologic diseases.


Hemorrhoidal recurrence 57
Hemorrhoids and other anal/rectal diseases 67

 Anal fissure 51

 Polipoid lesions 9

 Perianal fistula 4

 Perianal abscess 3

Stapled hemorrhoidopexy 27

[TableWrap ID: T2] Table 2 

Distribution of haemorrhoids degree in the study group.


II grade III grade IV grade tot
Men 7 309 137 443
Women 9 155 82 256

Total 16 464 219 699

[TableWrap ID: T3] Table 3 

Inclusion criteria of surgical treatment


Recurrent bleeding that may cause anaemia
Phlogistic or infective disorders (phlebitis, thrombophlebitis) recurring more than twice a year and forcing patients to stop their normal occupations

Mucous prolapse

Continuous or recurrent pruritus, to such an extent that it would make it socially unpleasant or cause lesions due to scratching

Sense of heaviness, of incomplete evacuation and tenesmus

[TableWrap ID: T4] Table 4 

Item of follow up registered in the postoperative period.


Early complications Late complications
Pain (VAS > 6) Slow wound healing
Urinary retention Incontinence
Bleeding Anal stenosis
Edema (> 2 days) Anal fissure
Infection
Fever (> 5 days)

[TableWrap ID: T5] Table 5 

Results of the study showing primary (pain) and secondary endpoints.


Before 1995 After 1995
At the discharge
Pts controlled after operation 479 (%) 220 (%)
Pain 138 (28,81)* 23 (10,45)*
Urinary retention 44 (9,19) 7 (3,18)
Bleeding 4 (0,83) 2 (0,9)
Edema 33 (6,89) 7 (3,18)
Infection 4 (0,83) 2 (0,9)
Fever (>5 GG.) 15 (3,13) 4 (1,81)
After one month
477 (%) 220 (%)
Slow wound healing 150 (31.44) 71 (32.27)
Incontinence 9 (1.88) 4 (1.81)
Stenosis 4 (0.83) 1 (0.45)
After six months
477 (%) 217 (%)
Anal fissure 19 (3.98) 4 (1,84)
Stenosis 2 (0.42) 1 (0.46)
Incontinence 6 (1.26) 3 (1.38)
After three years
322 (%) 210 (%)
Recurrence 7 (2.17) 6 (2.86)
Bleeding 22 (6.83) 25 (11.9)
Skin tags 13 (4.04) 15 (7.14)

*(χ2 : 10,880; p = 0,0001); 95% CI 24.7 to 28.9 (group A) and 10.17 to 10.72 (group B)



Article Categories:
  • Research Article


Previous Document:  Computational annotation of genes differentially expressed along olive fruit development.
Next Document:  Acupuncture for pain and osteoarthritis of the knee: a pilot study for an open parallel-arm randomis...