Document Detail


Internal friction in enzyme reactions.
MedLine Citation:
PMID:  23281036     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The empirical concept of internal friction was introduced 20 years ago. This review summarizes the results of experimental and theoretical studies that help to uncover the nature of internal friction. After the history of the concept, we describe the experimental challenges in measuring and interpreting internal friction based on the viscosity dependence of enzyme reactions. We also present speculations about the structural background of this viscosity dependence. Finally, some models about the relationship between the energy landscape and internal friction are outlined. Alternative concepts regarding the viscosity dependence of enzyme reactions are also discussed. ©2012 IUBMB Life, 65(1):35-42, 2013.
Authors:
Anna Rauscher; Imre Derényi; László Gráf; András Málnási-Csizmadia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IUBMB life     Volume:  65     ISSN:  1521-6551     ISO Abbreviation:  IUBMB Life     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888706     Medline TA:  IUBMB Life     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
Affiliation:
Department of Biochemistry, Eötvös University, Budapest, Hungary.
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