| Internal dosimetry for radiation therapy in coronary arteries. | |
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MedLine Citation:
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PMID: 12382782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute myocardial infarction, which occurs because of the occlusion of one or more coronary arteries, is the most common form of cardiovascular disease. Balloon angioplasty is often used to treat coronary artery occlusion and is less invasive than surgery involving revascularisation of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of re-stenosis after balloon angioplasty is high (approximately 30-50% within the first year after treatment). Intravascular radiation therapy has been used with several types of radiation source, and researchers have observed some success in decreasing the rate of re-stenosis. In this paper theoretical radiation dose distributions for monoenergetic electrons (with discrete energies) and photons are calculated for blood vessels of diameter 1.5, 3.0 and 4.5 mm with balloon and wire sources using the radiation transport code MCNP4B. Stent sources employing 32P are also simulated. Advantages and disadvantages of the radionuclides and source geometries are discussed, as well as issues regarding possible benefits to the patients. |
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Authors:
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L Compos; M Stabin |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiation protection dosimetry Volume: 101 ISSN: 0144-8420 ISO Abbreviation: Radiat Prot Dosimetry Publication Date: 2002 |
Date Detail:
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Created Date: 2002-10-17 Completed Date: 2003-04-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8109958 Medline TA: Radiat Prot Dosimetry Country: England |
Other Details:
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Languages: eng Pagination: 423-6 Citation Subset: IM |
Affiliation:
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Laboratoire de Chimie et Biophysique des Traceurs, Faculté de Médecine Xavier Bichat, Université Paris 7, France. lpbcampos@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary Coronary Stenosis / radiotherapy*, therapy* Coronary Vessels / anatomy & histology, radiation effects* Humans Myocardial Infarction / etiology Phosphorus Radioisotopes / therapeutic use Radioisotopes / therapeutic use Radiotherapy / methods* Radiotherapy Dosage Reproducibility of Results Rhenium / therapeutic use Stents |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes; 0/Radioisotopes; 7440-15-5/Rhenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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