| Internal atrial shock delivery by standard diagnostic electrophysiology catheters in goats: effects on atrial electrogram amplitude and tissue architecture. | |
| | |
MedLine Citation:
|
PMID: 17350984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: In this study, we evaluated the effects of atrial shock delivered via diagnostic electrophysiology catheters. METHODS AND RESULTS: In 11 anaesthetized goats, decapolar catheters were positioned in the right atrial appendage (RAA) and coronary sinus (CS). Three different catheters and two cardioversion protocols were evaluated. In four goats, 50 J shocks were delivered using catheters with 1 mm electrodes (surface area 70 mm(2)). In 6 goats, catheters with 2 mm electrodes (area 140 mm(2)) were used. In three of the six goats, 50 J shocks were given while in the other 3, 10 J shocks were delivered. In 1 goat 50 J shocks were delivered via 5 mm electrode catheters (area 310 mm(2)). No persisting adverse effects occurred. However, the electrogram amplitude at the RAA and CS decreased by >50-98% (P > 0.01). The amount of amplitude decrease was most pronounced at the CS site and for 50 J shocks. Goats were sacrificed after 9 +/- 1 days. Macroscopy revealed endocardial lesions at the electrode locations. Microscopy showed endocardial thrombosis, and necrosis with formation of granulation tissue. Changes were most marked with diagnostic catheters and 50 J shocks. CONCLUSIONS: Atrial shock delivery via diagnostic catheters causes local ablation lesions. The amount of amplitude decrease, macroscopic and microscopic damages were related to the energy applied and electrode surface area. |
| | |
Authors:
|
M C E F Wijffels; C C M M Timmermans; R J van Suylen; L M Rodriguez |
Related Documents
:
|
1715554 - Inability of the signal-averaged electrocardiogram to determine risk of arrhythmia recu... 9988004 - Can shocks timed to action potentials in low-gradient regions improve both internal and... 11084104 - Transvenous biventricular defibrillation. 19889504 - How to protect the heart in septic shock: a hypothesis on the pathophysiology and treat... 2944594 - Paucity of subtle myocardial injury after angioplasty delineated with mb ck. 3025894 - Immunological challenge with virus initiates leukotriene c4 production in the heart and... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-09 |
Journal Detail:
|
Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 9 ISSN: 1099-5129 ISO Abbreviation: Europace Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-30 Completed Date: 2007-06-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
|
Languages: eng Pagination: 203-7 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands. m.c.e.f.wijffels@lumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Artifacts* Atrial Function / radiation effects* Electric Countershock / methods* Electrocardiography / methods* Electrophysiologic Techniques, Cardiac / methods* Female Goats Heart Atria / anatomy & histology Heart Catheterization / methods* Heart Conduction System / anatomy & histology, physiology*, radiation effects |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evolution of left ventricular function in paediatric patients with permanent right ventricular pacin...
Next Document: In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin i...