Document Detail

Internal reflectivity of filtering blebs versus intraocular pressure in patients with recent trabeculectomy.
MedLine Citation:
PMID:  21228390     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The authors conducted a morphology analysis of filtering blebs with anterior segment optical coherence tomography (AS-OCT) in patients shortly after trabeculectomy to find further criteria for success or failure of a filtering bleb.
METHODS: Thirty-seven patients (43 eyes) who had recently (<2 years) undergone trabeculectomy were measured 1 to 4 times with AS-OCT. In contrast to ultrasound biomicroscopy, AS-OCT eliminates the need for a water bath in contact with the globe. This is of particular value in a study of morphologic parameters that may be altered by contact and in the postoperative period when concerns of infection are paramount. In this study, the internal reflectivity of the fluid-filled cavity of the filtering bleb was compared with the intraocular pressure (IOP).
RESULTS: Mean age of the patients was 69.5 years (range, 27-84 years). Average preoperative IOP of the 43 eyes was 20.6 mm Hg (range, 10-42 mm Hg), average postoperative IOP at the time of AS-OCT measurement was 10.6 mm Hg (range, 2-40 mm Hg), and mean IOP reduction was 10.0 mm Hg (48.5%). Internal reflectivity of the fluid-filled cavity of the filtering bleb correlated very well to the IOP (R(2) = 0.3762, n = 61, P < 0.0001).
CONCLUSIONS: AS-OCT is a promising tool with which to analyze the morphology of the filtering bleb after trabeculectomy. A highly significant correlation between the internal reflectivity of the fluid-filled cavity of the filtering bleb and the IOP could be shown that may have future impact in evaluating the postoperative success or failure of filtering blebs.
Lukas Pfenninger; Fabienne Schneider; Jens Funk
Publication Detail:
Type:  Journal Article     Date:  2011-04-14
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  52     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-15     Completed Date:  2011-06-22     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2450-5     Citation Subset:  IM    
Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland.
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MeSH Terms
Aged, 80 and over
Aqueous Humor / metabolism
Conjunctiva / metabolism,  pathology*
Glaucoma / physiopathology,  surgery*
Intraocular Pressure / physiology*
Microscopy, Acoustic
Middle Aged
Surgically-Created Structures / pathology*
Tomography, Optical Coherence

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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