Document Detail


Relationship of intermuscular fat volume in the thigh with knee extensor strength and physical performance in women at risk of or with knee osteoarthritis.
MedLine Citation:
PMID:  23044710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without.
METHODS: Baseline data from 125 women (age ≥50 years) in the Osteoarthritis Initiative study, with or at risk of knee ROA were included. Knee extensor strength was measured using a fixed force transducer, normalized to body mass (N/kg). Physical performance was the time required for 5 repeated chair stands (seconds). The IMF and QM volumes, normalized to height (cm(3) /meter), were yielded from analyses of T1-weighted axial magnetic resonance images of the midthigh. Mean IMF and QM volumes, extensor strength, and physical performance were compared between women with and without ROA, controlling for age. Hierarchical multiple regressions determined whether IMF and QM volumes were related to strength and performance after controlling for age, ROA status (yes/no), alignment, and pain.
RESULTS: Compared to subjects with ROA, the subjects without ROA were stronger and performed chair stands faster (P < 0.05). After adjusting for age, those subjects without ROA had less mean ± SD IMF (61.1 ± 20.3 cm(3) /meter) compared to mean ± SD ROA (72.0 ± 25.0 cm(3) /meter; P < 0.05). In the entire sample, 21.1% of variance in knee extensor strength was explained by alignment, pain, and IMF. A model explaining 13.4% of variance in physical performance included OA status and IMF. QM volume was unrelated to strength and physical performance.
CONCLUSION: IMF volume explained a small amount of variance in knee extensor strength and physical performance among women with or at risk of knee ROA.
Authors:
Monica R Maly; Kristina M Calder; Norma J Macintyre; Karen A Beattie
Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  65     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-02     Completed Date:  2013-03-14     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
Adiposity / physiology*
Aged
Cohort Studies
Female
Humans
Knee Joint*
Longitudinal Studies
Middle Aged
Muscle Strength / physiology*
Muscle, Skeletal / physiology*
Osteoarthritis, Knee / physiopathology*
Risk Factors
Thigh
Grant Support
ID/Acronym/Agency:
N01 AR022258/AR/NIAMS NIH HHS; N01 AR022259/AR/NIAMS NIH HHS; N01 AR022260/AR/NIAMS NIH HHS; N01 AR022261/AR/NIAMS NIH HHS; N01 AR022262/AR/NIAMS NIH HHS; N01-AR-2-2258/AR/NIAMS NIH HHS; N01-AR-2-2259/AR/NIAMS NIH HHS; N01-AR-2-2260/AR/NIAMS NIH HHS; N01-AR-2-2261/AR/NIAMS NIH HHS; N01-AR-2-2262/AR/NIAMS NIH HHS
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