Document Detail


Intermolecular cross-links in collagen of human placenta.
MedLine Citation:
PMID:  518905     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. There are four reducible cross-links in human placenta collagen. The principal one is dehydrodihydroxylysinorleucine. the next in abundance is dehydrohydroxylysinorleucine. The minor components are dehydrolysinonorleucine and dehydrohistidinohydroxymerodesmosine. 2. With increasing length of gestation, the collagen incorporates more tritium radioactivity into its reducible cross-links, with its maximum incorporation at the second trimester. The uptake declines thereafter. 3. Alkaline hydrolysis reveals that both dehydrodihydroxylysinonorleucine and dehydrohydroxylysinonorleucine occur in vivo partly as glycosylated complexes.
Authors:
K Y Kao; J G Leslie
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  580     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-03-24     Completed Date:  1980-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chemical Phenomena
Chemistry
Collagen / metabolism*
Female
Gestational Age
Humans
Hydrolysis
Peptides / metabolism
Placenta / metabolism*
Pregnancy
Chemical
Reg. No./Substance:
0/Peptides; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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