Document Detail

Intermittent vs continuous hypoxia: effects on ventilation and erythropoiesis in humans.
MedLine Citation:
PMID:  11055563     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recently, we showed that 5 days of normobaric intermittent hypoxia at rest (IH; 2 hours daily at 3,800 m simulated altitude; partial pressure of inspired oxygen 90 torr) can induce an increase in the isocapnic hypoxic ventilatory response (HVR) and blood reticulocyte count. The purpose of the present study was to compare these data with continuous exposure to the same hypoxic level. METHODS: Four of the same subjects were exposed, a year later, to 2 days of continuous hypoxia (CH), and 4 different subjects were exposed to 8 weeks of CH, both at the White Mountain Research Station (3,800 m altitude, barometric pressure approximately 489 torr). Inspired minute ventilation (VI), end-tidal partial pressure of carbon dioxide, arterial oxygen saturation (SaO2[sat]), hematocrit, and hemoglobin concentration were measured at different times during the continuous exposures. The HVR was expressed as the increase in V1 per 1% decrease in SaO2. RESULTS: The HVR showed no significant difference in the control values 1 year apart (IH, 0.06 +/- 0.03; CH2d (2 days' continuous hypoxia), 0.19 +/- 0.07 L x min(-1) x %sat(-1); means +/- SE), and the HVR values were similar after 2 days of IH compared to CH (0.42 +/- 0.26 and 0.51 +/- 0.22 L x min(-1) x %sat(-1), respectively). On the new subjects after 2 weeks of CH, the HVR showed a maximum increase, similar to the increase observed after only 5 days of IH, hemoglobin concentrations and hematocrit were significantly increased (45.0 +/- 2.7% vs 51.5 +/- 3.0% and 14.5 +/- 0.7 vs 17.2 +/- 1.0 g x dL(-1), respectively). The HVR did not change significantly from week 2 to 8 of CH, whereas hematological data were still increasing at the end of the 8 weeks. CONCLUSION: Changes in ventilatory oxygen sensitivity induced by IH and CH are similar in magnitude but occur with different time courses. The effects of IH on erythropoiesis are significant but fewer than on CH.
N Garcia; S R Hopkins; F L Powell
Related Documents :
14512283 - Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and...
1858883 - Effects of hypoxia and ischemia on autoregulation in postnatal intestine.
457863 - Effects of carnitine in ischemic and fatty acid supplemented swine hearts.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Wilderness & environmental medicine     Volume:  11     ISSN:  1080-6032     ISO Abbreviation:  Wilderness Environ Med     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-02     Completed Date:  2000-12-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505185     Medline TA:  Wilderness Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  172-9     Citation Subset:  IM    
Laboratoire Réponses Cellulaires et Fonctionnelles à l'hypoxie, UFR Médecine, Université Paris, Bobigny, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Altitude Sickness / physiopathology
Anoxia / physiopathology*
Erythrocyte Count
Reference Values
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Venomous snakebites in an urban area: what are the possibilities?
Next Document:  Effects of a negative pressure venom extraction device (Extractor) on local tissue injury after arti...