Document Detail


Intermittent therapy for melasma in Asian patients with combined topical agents (retinoic acid, hydroquinone and hydrocortisone): clinical and histological studies.
MedLine Citation:
PMID:  9798345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melasma is a common problem in Asians, but treatments have not been satisfactory. In the present study, we evaluated the efficacy of a new formula containing 0.1% tretinoin, 5% hydroquinone, and 1% hydrocortisone (RHQ) in Korean patients with melasma. Twenty-five Korean females with therapy recalcitrant melasma applied RHQ on their faces for 4 months and were evaluated before and 4 weeks after treatment clinically and histologically. They were also evaluated clinically 4 months after treatment. To minimize unavoidable side effects (erythema or peeling), we applied RHQ twice a week instead of the usual daily application. However, we obtained clinical and histological results comparable to other reports from white populations. Statistically significant depigmentation in clinical and histological studies and increased subepidermal collagen synthesis were observed in this study. These effects were seen as early as 4 weeks after treatment with RHQ. We used mMASI scoring, a modified version of the original MASI, to quantify the effects of RHQ more objectively and easily.
Authors:
W H Kang; S C Chun; S Lee
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of dermatology     Volume:  25     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-24     Completed Date:  1998-11-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  587-96     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Anti-Inflammatory Agents / administration & dosage*,  adverse effects
Asian Continental Ancestry Group
Dermis / pathology
Drug Administration Schedule
Drug Therapy, Combination
Epidermis / pathology
Female
Follow-Up Studies
Humans
Hydrocortisone / administration & dosage*,  adverse effects
Hydroquinones / administration & dosage*,  adverse effects
Keratolytic Agents / administration & dosage*,  adverse effects
Melanosis / drug therapy*,  ethnology,  pathology
Middle Aged
Radiation-Protective Agents / administration & dosage*,  adverse effects
Treatment Outcome
Tretinoin / administration & dosage*,  adverse effects
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Hydroquinones; 0/Keratolytic Agents; 0/Radiation-Protective Agents; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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