| Intermittent therapy for melasma in Asian patients with combined topical agents (retinoic acid, hydroquinone and hydrocortisone): clinical and histological studies. | |
| | |
MedLine Citation:
|
PMID: 9798345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Melasma is a common problem in Asians, but treatments have not been satisfactory. In the present study, we evaluated the efficacy of a new formula containing 0.1% tretinoin, 5% hydroquinone, and 1% hydrocortisone (RHQ) in Korean patients with melasma. Twenty-five Korean females with therapy recalcitrant melasma applied RHQ on their faces for 4 months and were evaluated before and 4 weeks after treatment clinically and histologically. They were also evaluated clinically 4 months after treatment. To minimize unavoidable side effects (erythema or peeling), we applied RHQ twice a week instead of the usual daily application. However, we obtained clinical and histological results comparable to other reports from white populations. Statistically significant depigmentation in clinical and histological studies and increased subepidermal collagen synthesis were observed in this study. These effects were seen as early as 4 weeks after treatment with RHQ. We used mMASI scoring, a modified version of the original MASI, to quantify the effects of RHQ more objectively and easily. |
| | |
Authors:
|
W H Kang; S C Chun; S Lee |
Related Documents
:
|
10569535 - Extracorporeal shock wave lithotripsy versus ureteroscopy for distal ureteral calculi: ... 12955705 - Acquired reactive perforating collagenosis in a nondiabetic hemodialysis patient: succe... 8571615 - High dose methotrexate infusion with leucovorin rescue for treatment of ectopic pregnancy. 9876745 - Non-gynecologic laparoscopy in second and third trimester pregnancy: obstetric implicat... 9018725 - The relationship between maternal birthweight and gestational age in twins and singleto... 8254595 - Vaginal birth after cesarean section. acceptance and outcome at a rural hospital. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of dermatology Volume: 25 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 1998 Sep |
Date Detail:
|
Created Date: 1998-11-24 Completed Date: 1998-11-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 587-96 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, Ajou University School of Medicine, Suwon, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Adult Anti-Inflammatory Agents / administration & dosage*, adverse effects Asian Continental Ancestry Group Dermis / pathology Drug Administration Schedule Drug Therapy, Combination Epidermis / pathology Female Follow-Up Studies Humans Hydrocortisone / administration & dosage*, adverse effects Hydroquinones / administration & dosage*, adverse effects Keratolytic Agents / administration & dosage*, adverse effects Melanosis / drug therapy*, ethnology, pathology Middle Aged Radiation-Protective Agents / administration & dosage*, adverse effects Treatment Outcome Tretinoin / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Inflammatory Agents; 0/Hydroquinones; 0/Keratolytic Agents; 0/Radiation-Protective Agents; 123-31-9/hydroquinone; 302-79-4/Tretinoin; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pruritus gravidarum: a clinical and laboratory study.
Next Document: Acquired reactive perforating collagenosis with IgA nephropathy.