Document Detail


Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: a randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle.
MedLine Citation:
PMID:  18359127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Intermittent dosing of a topical calcineurin inhibitor for preventing atopic dermatitis (AD) disease relapse in patients with stabilized AD has not been evaluated. OBJECTIVE: We sought to evaluate the long-term efficacy and safety of 3-times-weekly use of tacrolimus ointment in preventing AD disease relapse. METHODS: Adult and pediatric patients with moderate to severe AD who were clear of disease after up to 16 weeks of treatment with tacrolimus ointment were randomized in a double-blind fashion to 3-times-weekly treatment with either tacrolimus ointment (0.03% or 0.1%) or vehicle for 40 weeks. The primary end point was the number of flare-free treatment days. RESULTS: A total of 125 patients were randomized to tacrolimus and 72 patients to vehicle. The mean number of flare-free treatment days was 177 for tacrolimus and 134 for vehicle (P = .003). Median time to first relapse was 169 days for tacrolimus and 43 for vehicle (P = .037). LIMITATIONS: Generalizability to all patients seen in clinic may be limited because only patients who responded to tacrolimus ointment in the stabilization phase were randomized into the maintenance phase of the trial. CONCLUSIONS: Maintenance therapy with tacrolimus ointment was associated with significantly more flare-free days compared with vehicle, and a significantly longer time until first disease relapse.
Authors:
Debra Breneman; Alan B Fleischer; William Abramovits; Joshua Zeichner; Michael H Gold; Robert S Kirsner; Toni F Shull; Andrew W Crowe; Eileen Jaracz; Jon M Hanifin;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-03-21
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  58     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  990-9     Citation Subset:  IM    
Affiliation:
University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. debra.breneman@uc.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Dermatitis, Atopic / prevention & control*
Double-Blind Method
Drug Administration Schedule
Female
Humans
Immunosuppressive Agents / administration & dosage*
Male
Ointments
Tacrolimus / administration & dosage*
Time Factors
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Ointments; 109581-93-3/Tacrolimus
Investigator
Investigator/Affiliation:
Cheryl Aber / ; Herb Alexander / ; Nancy Anderson / ; Melanie Appell / ; Richard Antaya / ; M Shane Chapman / ; Bernard Cohen / ; Lawrence F Eichenfield / ; Steven Feldman / ; Linda Stein Gold / ; Julia E Graves / ; Sewon Kang / ; Anne Laumann / ; Kenneth Linden / ; Amit Pandya / ; Amy S Paller / ; Eric Simpson / ; Mark Lebwohl /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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