Document Detail


Intermittent roxithromycin for preventing progression of small abdominal aortic aneurysms: long-term results of a small clinical trial.
MedLine Citation:
PMID:  19640922     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antibodies against Chlamydia pneumoniae are associated with an increased rate of expansion of small abdominal aortic aneurysms (AAAs). Short-term follow-up trials have shown a transient reduction AAA growth rate, in macrolide treated compared with placebo. Therefore we analysed the influence of intermittent, long-term roxithromycin treatment on AAA expansion and referral for surgery. METHODS: Eighty-four patients with small AAAs were randomized to either an annual 4 weeks' treatment with roxithromycin or placebo, and followed prospectively. RESULTS: Intermittent, long-term Roxithromycin-treatment reduced mean annual growth rate by 36% compared with placebo after adjustment for potential confounders. Long-term roxithromycin-treated patients had a 29% lower risk of being referred for surgical evaluation, increasing to 57% after adjusting for potential confounders. CONCLUSION: Annual 4 week treatment with 300 mg roxithromycin daily may reduce the progression of small AAAs, and later need for surgical repair. However, more robust studies are needed for confirmation.
Authors:
Annette Høgh; Steen Vammen; Lars Ostergaard; Jette B Joensen; Esklid W Henneberg; Jes S Lindholt
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-07-29
Journal Detail:
Title:  Vascular and endovascular surgery     Volume:  43     ISSN:  1538-5744     ISO Abbreviation:  Vasc Endovascular Surg     Publication Date:    2009 Oct-Nov
Date Detail:
Created Date:  2009-10-23     Completed Date:  2009-12-15     Revised Date:  2010-09-21    
Medline Journal Info:
Nlm Unique ID:  101136421     Medline TA:  Vasc Endovascular Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-6     Citation Subset:  IM    
Affiliation:
Vascular Research Unit, Department of Vascular Surgery, Viborg Hospital, Denmark. a_l_hogh@yahoo.dk
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Bacterial Agents / administration & dosage*
Aortic Aneurysm, Abdominal / drug therapy*,  pathology
Double-Blind Method
Drug Administration Schedule
Follow-Up Studies
Humans
Male
Middle Aged
Roxithromycin / administration & dosage*
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 80214-83-1/Roxithromycin
Comments/Corrections
Comment In:
Vasc Endovascular Surg. 2010 Oct;44(7):613-4   [PMID:  20675312 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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