Document Detail


Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence.
MedLine Citation:
PMID:  22775553     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Malaria continues to represent a huge global health burden on the most vulnerable populations. The Intermittent Preventive Treatment (IPT) strategy has been shown to be an efficacious intervention in preventing most of the deleterious effects of malaria in pregnant women and infants. Yet, the effectiveness of the IPT strategy may be impaired by the increasing resistance to sulfadoxine-pyrimethamine (SP), and the scarcity of alternative antimalarial drugs.
AREAS COVERED: This review examines all the available information on IPT, in an aim to provide the scientific community with a framework to understand the benefits and limitations of this malaria control strategy. It includes the understanding of the historical background of the IPT strategy, the drug's mechanisms of actions, updated information on current available evidence, the implications of drug resistance and choice of alternative drugs, and a comprehensive discussion on the perspectives of IPT for malaria control in pregnant women and infants.
EXPERT OPINION: IPT in pregnancy and infants is a cost-effective strategy that can contribute significantly to the control of malaria in endemic areas. Monitoring its effectiveness will allow tracking of progress, evaluation of the adequacy of currently used drugs and will highlight the eventual need for new therapies or alternative interventions.
Authors:
Azucena Bardají; Quique Bassat; Pedro L Alonso; Clara Menéndez
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-07-09
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  13     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-19     Completed Date:  2012-11-27     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1719-36     Citation Subset:  IM    
Affiliation:
University of Barcelona, Hospital Clínic, Barcelona Centre for International Health Research, Roselló, 132, 08036, Barcelona, Spain. abardaji@clinic.ub.es
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MeSH Terms
Descriptor/Qualifier:
Antimalarials / administration & dosage*,  economics
Cost-Benefit Analysis
Drug Administration Schedule
Drug Resistance
Female
Humans
Immunity, Innate / drug effects
Infant
Infant, Newborn
Malaria / economics,  immunology,  prevention & control*
Pregnancy
Pregnancy Complications, Parasitic / prevention & control*
Chemical
Reg. No./Substance:
0/Antimalarials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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