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Intermittent positive pressure ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvre during inhalation anaesthesia in horses undergoing surgery for colic, and its influence on the early recovery period.
MedLine Citation:
PMID:  21492381     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective  To compare, ventilation using intermittent positive pressure ventilation (IPPV) with constant positive end-expiratory pressure (PEEP) and alveolar recruitment manoeuvres (RM) to classical IPPV without PEEP on gas exchange during anaesthesia and early recovery. Study design  Prospective randomized study. Animals  Twenty-four warm-blood horses, weight mean 548 ± SD 49 kg undergoing surgery for colic. Methods  Premedication, induction and maintenance (isoflurane in oxygen) were identical in all horses. Group C (n = 12) was ventilated using conventional IPPV, inspiratory pressure (PIP) 35-45 cmH(2) O; group RM (n = 12) using similar IPPV with constant PEEP (10 cmH(2) O) and intermittent RMs (three consecutive breaths PIP 60, 80 then 60 cmH(2) O, held for 10-12 seconds). RMs were applied as required to maintain arterial oxygen tension (PaO(2) ) at >400 mmHg (53.3 kPa). Physiological parameters were recorded intraoperatively. Arterial blood gases were measured intra- and postoperatively. Recovery times and quality of recovery were measured or scored. Results  Statistically significant findings were that horses in group RM had an overall higher PaO(2) (432 ± 101 mmHg) than those in group C (187 ± 112 mmHg) at all time points including during the early recovery period. Recovery time to standing position was significantly shorter in group RM (49.6 ± 20.7 minutes) than group C (70.7 ± 24.9). Other measured parameters did not differ significantly. The median (range) of number of RMs required to maintain PaO(2) above 400 mmHg per anaesthetic was 3 (1-8). Conclusion  Ventilation using IPPV with constant PEEP and RM improved arterial oxygenation lasting into the early recovery period in conjunction with faster recovery of similar quality. However this ventilation mode was not able to open up the lung completely and to keep it open without repeated recruitment. Clinical relevance  This mode of ventilation may provide a clinically practicable method of improving oxygenation in anaesthetized horses.
Authors:
Klaus Hopster; Sabine Br Kästner; Karl Rohn; Berhard Ohnesorge
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary anaesthesia and analgesia     Volume:  38     ISSN:  1467-2995     ISO Abbreviation:  Vet Anaesth Analg     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100956422     Medline TA:  Vet Anaesth Analg     Country:  England    
Other Details:
Languages:  eng     Pagination:  169-77     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Veterinary Anaesthesia and Analgesia © 2011 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.
Affiliation:
Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany Department of Biometry, Epidemiology and Information Processing, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
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