Document Detail

Intermittent left bundle branch block caused by coronary vasospasm.
Jump to Full Text
MedLine Citation:
PMID:  23930243     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Intermittent left bundle branch block (LBBB) has been reported in the literature following certain conditions such as cardiac blunt trauma, myocardial infarction (MI) or exercise induced LBBB. In the majority of cases, the patients usually have underlying coronary arteries disease. LBBB often prevents the electrocardiographic diagnosis of acute MI; therefore, new LBBB in the setting of chest pain is usually treated as transmural MI. We describe a case of patient who presented with intermittent LBBB associated with chest pain, and subsequently the patient was taken to the catheterization laboratory for emergency coronary angiogram, which revealed 80% spasm in left anterior descending artery, which was totally relieved by nitroglycerin infusion. No other significant CAD was noted.
Mohammad Alhaji
Related Documents :
3761563 - Coronary angiography after myocardial infarction. a comparison between a japanese commu...
15276103 - Effectiveness of sirolimus-eluting stent implantation for treatment of in-stent resteno...
2978163 - Immunohistocytochemical localization of alpha human atrial natriuretic peptide in human...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Avicenna journal of medicine     Volume:  3     ISSN:  2231-0770     ISO Abbreviation:  Avicenna J Med     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-08-09     Completed Date:  2013-08-09     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  101584155     Medline TA:  Avicenna J Med     Country:  India    
Other Details:
Languages:  eng     Pagination:  50-2     Citation Subset:  -    
Department of Hospital Medicine, Saint Joseph Mercy Health System, Ann Arbor, MI, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Avicenna J Med
Journal ID (iso-abbrev): Avicenna J Med
Journal ID (publisher-id): AJM
ISSN: 2231-0770
ISSN: 2249-4464
Publisher: Medknow Publications & Media Pvt Ltd, India
Article Information
Copyright: © Avicenna Journal of Medicine
Print publication date: Season: Apr-Jun Year: 2013
Volume: 3 Issue: 2
First Page: 50 Last Page: 52
PubMed Id: 23930243
ID: 3734632
Publisher Id: AJM-3-50
DOI: 10.4103/2231-0770.114129

Intermittent left bundle branch block caused by coronary vasospasm
Mohammad Alhajiaff1
Department of Hospital Medicine, Saint Joseph Mercy Health System, Ann Arbor, MI, USA
Correspondence: Address for correspondence: Dr. Mohammad Alhaji, Department of Hospital Medicine, Saint Joseph Mercy Health System, Ann Arbor, MI, USA. E-mail:


Intermittent left bundle branch block (LBBB) is an uncommon conduction disturbance with only few cases reported in the literature, mainly following myocardial ischemia or cardiac blunt trauma. Coronary vasospasm as a leading cause of intermittent LBBB has not been reported before. We present a case of middle-aged women with presentation of cardiac chest pain with intermittent LBBB in Electrocardiogram (EKG/ECG). The patient was taken to the catheterization laboratory immediately. The angiogram ultimately showed clean coronaries and moderate-severe vasospasm in left anterior descending artery (LAD), which totally relieved by vasodilators.


A 53-year-old African American female with past medical history of diabetes mellitus, hypertension and dyslipidemia, presented to the hospital with 3 days history of intermittent chest pain. She described the pain as severe retrosternal, non-exertional, radiating to the left arm lasting for 20-30 min and is associated with severe diaphoresis and shortness of breath. It used to occur 3-5 times a day and relieved spontaneously or by sublingual Nitroglycerin (NTG). The patient had 15 pack year's history of smoking, occasional alcohol intake and no illicit drug use.

On physical examination, she was hemodynamically stable, blood pressure of 115/52 mmHg, pulse of 78 bpm, with normal saturation on room air. The pain quickly resolved by sublingual nitroglycerin and IV morphine, cardiac exam showed 2/6 systolic ejection murmur at aortic area with no radiation, heart sounds were normal with regular rate and rhythm, there was no jugular venous distention, lungs were clear, pulses were strong and equal in all limbs and there was no edema in the lower extremities. Serial EKG/ECG were obtained, it consistently showed (LBBB) during chest pain episodes [Figure 1], and resolution of the LBBB pattern with deep T wave inversion in Leads V1-V4 during chest-pain-intervals [Figure 2].

Patient was started on aspirin 325 mg, loading dose of clopidogrel 600 mg, heparin drip, and was subsequently taken for emergent coronary angiogram. By the time, she arrived to Cath Lab, the chest pain was substantially improved. The coronary angiogram showed clean coronary arteries except of 80% LAD vasospasm, which was relieved by intravenous nitroglycerin. Cardiac enzymes were negative. Echocardiogram showed normal left ventricular ejection fraction without any regional wall motion abnormalities. The diagnosis of coronary vasospasm was made and the patient was started on calcium channel blocker (Diltiazem) daily, which provided symptomatic relief. Patient did well during 10 months follow-up period with further chest pain episodes.


Coronary Vasospasm (Prinzmetal, s Angina) is characterized by episodes of angina in association with EKG/ECG changes, typically S-T segment elevation.[1] The spasm usually happens regardless of presence of increase in myocardial oxygen demand or not, and also it might happen in normal or diseased vessels.[2, 3] In the majority of the cases, the coronary vasospasm occurs in one single site, although diffuse spasm has been described before.[4] Cocaine abuse has been reported frequently in the literature to be associated with coronary vasospasm,[5] other characteristics include circadian variation,[6] exercise and hyperventilation,[7] and the patients are typically younger than those who present with acute coronary syndrome.

LBBB is a common pattern seen on the EKG/ECG. It usually presents in patients with underlying heart disease or conducting system disease. LBBB can be rate-dependent where the LBBB is seen at a critical heart rate.[8] There are two forms of rate-dependent LBBB: The acceleration-dependent block form, in which conduction delay occurs when the heart rate exceeds a critical value, and the deceleration dependent block in which conduction delay occurs when the heart rate decreases below a critical level.[9, 10]

Intermittent LBBB was reported in the literature following few conditions such as cardiac blunt trauma,[11] myocardial ischemia,[12] exercise induced LBBB[13] or myocardial infarction. Most of the time, it presents in patients with underlying coronary arteries disease, and rarely described in patients with normal coronary vasculatures.

This case is unique as for the first time in the literature, we report a coronary vasospasm associated with intermittent LBBB. Most of the time, coronary angiogram is needed to rule out coronary artery disease. Coronary vasospasm does not always present during the coronary catheterization. Therefore, it should be speculated based on the clinical presentation.


Source of Support: Nil

Conflict of Interest: None declared.

1. Prinzmetal M,Kennamer R,Merliss R,Wada T,Bor N. Angina pectoris. I. A variant form of angina pectoris; preliminary reportAm J MedYear: 1959273758814434946
2. Yilmaz A,Sechtem U. Angina pectoris without coronary stenosis – Current conceptsDtsch Med WochenschrYear: 201013519253020830663
3. Yasue H,Takizawa A,Nagao M,Nishida S,Horie M,Kubota J. Role of coronary spasm in different anginal syndromesActa Med Scand SupplYear: 198569483943859197
4. Okumura K,Yasue H,Matsuyama K,Ogawa H,Kugiyama K,Ishizaka H,et al. Diffuse disorder of coronary artery vasomotility in patients with coronary spastic angina. Hyperreactivity to the constrictor effects of acetylcholine and the dilator effects of nitroglycerinJ Am Coll CardiolYear: 19962745528522709
5. Benzaquen BS,Cohen V,Eisenberg MJ. Effects of cocaine on the coronary arteriesAm Heart JYear: 20011424021011526352
6. Ogawa H,Yasue H,Oshima S,Okumura K,Matsuyama K,Obata K. Circadian variation of plasma fibrinopeptide A level in patients with variant anginaCirculationYear: 1989801617262532074
7. Previtali M,Ardissino D,Barberis P,Panciroli C,Chimienti M,Salerno JA. Hyperventilation and ergonovine tests in Prinzmetal's variant angina pectoris in menAm J CardiolYear: 19896317202909157
8. Frisch DR,Zimetbaum PJ,Josephson ME. Alternating left bundle branch block and right bundle branch block during tachycardia: What is the mechanism?Heart RhythmYear: 200746798017467642
9. Calabrò MP,Cerrito M,Luzza F,Oreto G. Alternating right and left bundle branch block aberration during atrial tachycardiaJ ElectrocardiolYear: 200942633519376525
10. Patanè S,Marte F,Di Bella G. Changing axis deviation with changing bundle branch block and new-onset of atrial fibrillation during acute myocardial infarctionInt J CardiolYear: 2009132e1283018068830
11. Pizzo VR,Beer I,de Cleva R,Zilberstein B. Intermittent left bundle branch block (LBBB) as a clinical manifestation of myocardial contusion after blunt chest traumaEmerg Med JYear: 200522300115788845
12. Patanè S,Marte F,Di Bella G. Atrial fibrillation with left bundle branch block and intermittent right axis deviation during acute myocardial infarctionInt J CardiolYear: 2008127e1217418437
13. Eckart RE,Field ME,Hruczkowski TW,Forman DE,Dorbala S,Di Carli MF,et al. Association of electrocardiographic morphology of exercise-induced ventricular arrhythmia with mortalityAnn Intern MedYear: 200814945160 W82. 18838725


[Figure ID: F1]
Figure 1 

When the chest pain presents: Shows left bundle branch block

[Figure ID: F2]
Figure 2 

Chest-pain free shows deep T waves inversion in pericardial leads

Article Categories:
  • Case Report

Keywords: Chest pain, coronary vasospasm, left bundle branch block.

Previous Document:  Posterior tracheal wall leading to life-threatening obstruction of tracheostomy tube.
Next Document:  Alcoholic leukopenic pneumococcal sepsis.